How does low progesterone cause fetal arrest?

Once fetal arrest occurs, some of the pregnant woman's pregnancy reactions will gradually disappear. However, there are many reasons that lead to fetal arrest, and low progesterone is a common phenomenon. So what exactly is going on? Let us introduce it below.

Progesterone is a natural progestogen secreted by the corpus luteum of the ovary. It has a significant morphological effect on the endometrium stimulated by estrogen in the body and is necessary for maintaining pregnancy. Progesterone is clinically used for the reactive diagnosis of amenorrhea or causes of amenorrhea, such as threatened abortion and habitual abortion. If the progesterone level is too low, pregnancy cannot be maintained.

Embryo implantation and continued development depend on the coordination of a complex endocrine system. Any abnormality in any link can lead to miscarriage. During the early development of the embryo, three important hormone levels are required: estrogen, progesterone, and human chorionic gonadotropin. As for the mother, if her own endogenous hormones are insufficient, it cannot meet the needs of the embryo and may cause embryo arrest and miscarriage.

The most common of these is luteal dysfunction, which can cause delayed endometrial development and a short luteal phase, thereby affecting the implantation of the fertilized egg or early pregnancy miscarriage. People with luteal insufficiency are often accompanied by other glandular dysfunctions, such as hyperthyroidism or hypothyroidism, diabetes, relative androgenism and hyperprolactinemia. These factors are not conducive to embryonic development and are closely related to miscarriage.