What does it mean to analyze the critical risk of Down syndrome screening?

The critical risk of Down syndrome screening is actually to better judge the risk factor of congenital idiocy neural tube defects in the fetus. If the screening result is a critical risk, it means that there is a certain chance of getting the disease, so further examination is required.

1. What does the critical risk of Down syndrome screening mean?

Down syndrome screening is the abbreviation for prenatal screening test for Down syndrome. The purpose is to test the blood of pregnant women to detect the concentrations of alpha-fetoprotein, human chorionic gonadotropin and free estriol in the maternal serum, and to determine the risk factor of the fetus suffering from congenital idiocy and neural tube defects based on the age, weight and gestational age of the pregnant woman. The critical risk of Down syndrome screening is a critical value risk, which means that there is a certain chance of getting the disease. It is recommended that you go to the hospital for amniocentesis, which has a higher accuracy rate than Down syndrome screening, but has certain risks. Mom can think about it herself.

2. Inspection significance

Down syndrome screening is aimed at specific people who do not have any corresponding disease indicators (such as all pregnant women). Through examination, high-risk groups with a higher possibility of Down syndrome are screened out for subsequent diagnostic examinations. There is currently no medical cure for Down syndrome, so the main approach to controlling the occurrence of Down syndrome is to prevent or reduce the birth of children with the disease. But one thing that needs to be made clear is that the purpose of screening is not to diagnose a certain disease, but to screen out people who are more likely to have a certain disease.

3. Necessity

Any pregnant woman has the potential to conceive a baby with Down syndrome. "According to the results of the Ministry of Health's hospital-based birth defect monitoring from 2001 to 2006, 800,000 to 1.2 million children with birth defects are born in my country every year." Down syndrome screening is a general survey conducted on all pregnant women in my country to prevent the birth of children with congenital mental retardation.

From a medical perspective, Down syndrome screening is very necessary and expectant mothers must pay enough attention to it. Down syndrome screening can reduce the birth rate of children with Down syndrome. Children with Down syndrome will suffer from severe multiple congenital malformations (special facial features, congenital heart disease, major organ dysfunction and limb abnormalities), accompanied by severe mental retardation and are basically unable to take care of themselves. Most children die before they reach adulthood. Therefore, in order to prevent the birth of children with congenital idiocy and to achieve early detection and early resolution, prenatal Down syndrome screening is very important. Data show that "through strict quality-controlled early pregnancy NT screening, the detection rate of 21-trisomy fetuses can exceed 80%, and the detection rate of other chromosomal abnormalities can exceed 70%. If combined with maternal serum examination, the detection rate can be further improved."