Many female friends become irritable and angry when their menstruation comes. In fact, this is what we call premenstrual syndrome. The reason for this situation is mostly related to the imbalance of estrogen and progesterone and mental factors. (1) Imbalance in the ratio of estrogen to progesterone: This can be caused by relatively high estrogen levels and relatively insufficient progesterone levels; it can also be caused by abnormal tissue sensitivity to progesterone. Under normal circumstances, progesterone promotes the excretion of sodium and water in the distal renal tubules, while estrogen causes water and sodium retention through the renin, angiotensin II, and aldosterone system. Therefore, an imbalance in the ratio of estrogen to progesterone can cause signs such as weight gain. (2) Vitamin B6 deficiency: Vitamin B6 can promote the elimination of excess estrogen in the body and alleviate emotions and behaviors. A lack of vitamin B6 may cause premenstrual syndrome. (3) Mental factors: Some patients have prominent mental symptoms. Emotional fluctuations and mental stress can aggravate the original symptoms. (4) Endorphin theory: Since changes in endorphin levels can affect mental and neurological factors, intravenous administration of endorphins can increase prolactin concentrations. Animal experiments also show that antidiuretic hormone increases after endorphin administration. The endorphin inhibitor naloxone can change the secretion of luteinizing hormone after acting on the endorphin receptors, and β-endorphin changes with the menstrual cycle. Therefore, it is proposed that premenstrual tension syndrome is caused by changes in endorphin concentrations during the luteal phase. |
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