Normal value of progesterone after pregnancy and its clinical significance

We all know that each of us comes into this world by being born from our mother’s belly. Our mothers carry us for ten months and give birth to us successfully. Many people may want to know how a life is born? In fact, it takes a long process for our sperm and egg cells to combine and hatch in the mother's body. Maybe everyone is particularly interested in the issue of progesterone after pregnancy. Let us learn about the relevant content of progesterone after pregnancy.

Normal value:

Follicular phase: early 0.7±0.1ng/ml; late 0.4±0.1ng/ml

Ovulation period: 1.6±0.2ng/ml

Luteal phase: early 11.6±1.5ng/ml; mid-phase 22.5±1.5ng/ml; late 5.7±1.1ng/ml.

Clinical Application:

1. Monitor ovulation: blood progesterone level >15.6nmol/L indicates ovulation. If the progesterone level is consistent with ovulation and the patient has infertility without other reasons, B-type ultrasound examination is necessary to observe the follicular development and ovulation process to exclude luteinized unruptured follicle syndrome (LUFS). When using ovulation-inducing drugs, the blood progesterone level can be used to observe the ovulation-inducing effect. If multiple ovulation occurs and multiple corpora lutea are produced, the blood progesterone level may increase. Primary or secondary amenorrhea, anovulatory menstruation or anovulatory dysfunctional uterine bleeding, polycystic ovary syndrome, oral contraceptives or long-term use of GnRH agonists can all reduce progesterone levels.

2. Understand the function of the corpus luteum: If the blood progesterone level during the luteal phase is lower than the physiological value, it indicates insufficient corpus luteum function; if the blood progesterone level is still higher than the physiological level 4-5 days after menstruation, it indicates incomplete atrophy of the corpus luteum.

3. Understand the status of pregnancy: After ovulation, if the egg is fertilized, the corpus luteum continues to secrete progesterone. Starting from the 7th week of pregnancy, the placenta secretes progesterone in an amount that exceeds the corpus luteum of the ovary. When placental function declines during pregnancy, progesterone levels in the blood decrease. In case of ectopic pregnancy, the progesterone level is low. If the progesterone level is >78.0nmol/L (25ng/ml), ectopic pregnancy can be basically ruled out. If the single progesterone level is ≤15.6nmol/L (5ng/ml), it indicates a stillbirth. During threatened miscarriage, if the progesterone level shows a downward trend, miscarriage may occur. The amount of urinary pregnanediol excretion during pregnancy varies greatly among individuals, making it difficult to estimate placental function, so it is rarely used clinically.

4. Monitoring of progesterone replacement therapy: After removal of the luteal ovary in early pregnancy, plasma progesterone levels should be monitored when natural progesterone replacement therapy is used.

The above content introduces us to the relevant content about progesterone after pregnancy, which satisfies the curiosity of many people. We know how we came to this world step by step and how we grew up step by step. We should all learn more about this knowledge so that we can realize that our life is hard-won.