What are the pathological classifications of endometrial hyperplasia?

The endometrium is an important component of the uterus and is prone to hyperplasia, also known as endometrial hyperplasia. It mainly occurs during menopause or adolescence and is related to abnormal hormone secretion by the ovaries. Understanding the pathological classification of endometrial hyperplasia can help us understand this disease more clearly. So, what are the pathological types of endometrial hyperplasia? Let’s take a closer look at them below.

The pathological classification of endometrial hyperplasia is based on the differences in cell morphology and the degree of proliferation and differentiation of glandular structures. There are three types:

1. Simple hyperplasia: The number of glands increases, and some glands expand into small cysts. The glandular epithelium is generally simple or pseudostratified, the cells are columnar, without atypia, and the cell morphology and arrangement are similar to those of the proliferative endometrium. The probability of progression to endometrial adenocarcinoma is 1%.

2. Complex hyperplasia: The glands proliferate significantly, and the glandular structure is complex and irregular. Due to the proliferation of glandular epithelial cells, they may grow in a papillary manner into the glandular cavity or in a budding manner into the stroma, without cell atypia. The intimal stroma was significantly reduced. The chance of developing adenocarcinoma is approximately 3%.

3. Atypical hyperplasia is based on complex hyperplasia and is accompanied by epithelial cell atypia, disordered cell polarity, increased volume, increased nuclear-cytoplasmic ratio, concentrated nuclear chromatin, prominent nucleoli, and varying numbers of nuclear division images. One-third of patients develop adenocarcinoma.

The above is an introduction to the pathological classifications of endometrial hyperplasia. I hope it will be helpful to patients’ understanding. The pathological classification of endometrial hyperplasia is relatively complicated. When suffering from this disease, it is best to go to a regular hospital for treatment. It is mainly based on your own condition to determine the appropriate treatment method, so that the disease can be eventually cured.