Why does polycystic ovary syndrome occur?

Why does polycystic ovary syndrome occur? Polycystic ovary syndrome is a common gynecological disease among infertile women. Because it can cause ovulation disorders, it can easily lead to infertility in women. Therefore, it is a disease that cannot be ignored for women. Moreover, because the disease has no obvious discomfort symptoms, many patients discover it relatively late, which also brings certain obstacles to the treatment of the disease. Therefore, I hope that all female friends can understand the cause of polycystic ovary syndrome and do a good job in preventing the disease.

The main causes of PCOS are:

1. Abnormal adrenal function 50% of PCOS patients have elevated dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS), increased activity of key enzymes that synthesize progesterone in the adrenal glands, and increased sensitivity and hyperfunction of adrenal cells to adrenocorticotropic hormone (ACTH). Hyperfunction of the adrenal cortex and excessive secretion of androgens can cause anovulation and symptoms similar to polycystic ovary.

2. Insulin resistance and hyperinsulinemia Some patients with polycystic ovary syndrome (PCOS), especially obese patients, may show hyperinsulinemia and insulin resistance, suggesting that it is caused by insulin resistance. There are many causes of insulin resistance. In most cases, it is caused by disorders in the information conduction system after the insulin receptor. There may also be insulin receptor defects. Hyperinsulinemia can inhibit the synthesis of sex hormone binding globulin (SHBG) in the liver and increase free androgens in the body. Androgens can also increase LH secretion through the pituitary insulin receptors.

3. Abnormal regulation of the hypothalamus-pituitary-ovarian axis. Mental stress, drugs and certain diseases affect the endocrine function of the hypothalamus-pituitary gland, increasing the sensitivity of the pituitary gland to Gn-RH, secreting excessive LH and causing dysfunction of cytochrome in the ovary, which serves as an androgen-forming enzyme. This leads to excessive androgen production by the ovarian interstitial and theca cells. High androgen levels in the ovaries inhibit follicle maturation and cause atresia of developing follicles, making it impossible to form dominant follicles, resulting in interruption of the normal estrogen secretion pattern. However, many small follicles still secrete estrogen. Therefore, patients with polycystic ovary syndrome (PCOS) have both high androgen and high estrogen, but the excess androgen is dominant.

After knowing why polycystic ovary syndrome occurs, I hope that all female friends here can truly realize the harm of polycystic ovary syndrome. You should know that this disease not only causes infertility, but also causes facial acne in women, which will cause more serious damage to women's appearance and have a certain impact on women's psychology. Therefore, it is recommended that all patients and friends must seek timely treatment.