Treatment of infertility caused by endocrine disorders

There are many reasons for female infertility. When women find themselves infertile, they should find the cause of the disease in time, so that they can choose the correct method for treatment. The common cause of female infertility is endocrine disorders. When endocrine disorders are serious, they will affect the female body. Therefore, women should prevent such problems. What are the methods for treating endocrine disorders infertility?

Treatment of endocrine disorder infertility:

Drug treatment

For patients who do not ovulate due to dysfunction of the hypothalamus-pituitary-ovarian axis, drugs can be used to induce ovulation:

(1) Clomiphene (clomiphene citrate): Starting from the 5th day of menstruation, take clomiphene citrate 50-150 mg/day orally for 5 consecutive days. Ovulation may occur 5-11 days after stopping the drug. If the estrogen level is low, you can first use a small dose of estrogen, diethylstilbestrol 0.125-0.25 mg/day, for 20 consecutive days and 1 to 3 cycles to increase the sensitivity of the hypothalamus-pituitary-ovarian system, and then use clomiphene to induce ovulation to improve the efficacy. If the cervical mucus is small and thick, add 0.125-0.25 mg/day of diethylstilbestrol after taking clomiphene for 7 consecutive days.

(2) Artificial cycle of estrogen and progesterone: For those with general menstrual disorders but a certain level of estrogen, estrogen and progesterone can be used sequentially for artificial cycle treatment for 3 months. Ovulation may occur after stopping the medication.

(3) Human chorionic gonadotropin (HCG): HCG has the effect of luteinizing hormone and can induce ovulation when administered when the follicles are nearly mature. ① Combination of clomiphene and HCG: Give clomiphene 50-150 mg/day for 5 consecutive days. On the 4th to 16th day of menstruation, or when E?2 in the blood is ≥1000PmoL/L, or when ultrasound shows that the diameter of the follicle is 2.0cm, give HCG 5000-10000iu intramuscular injection. ②Combination of clomiphene, HMG and H CG: Each vial of HMG contains 75iu of FSH and LH, which can promote the growth, development and maturation of follicles. Give clomiphene 50-150 mg/day for 5 days, and start intramuscular injection of 2 HMGs daily from the 6th day of menstruation for 6-8 days. When blood estradiol (E?2) ≥1000 Pmol/L and follicle diameter is 2.0 cm, stop human menopausal gonadotropin (HMG). 36 hours later, intramuscular injection of HCG 5000-10000iu should be given to induce ovulation.

(4) Luteinizing hormone-releasing hormone (LH-RH): Suitable for anovulators with insufficient secretion of the hypothalamus. Use micropump pulse intravenous injection, with pulse intervals of 90 to 120 minutes, small doses of 1 to 5 μg/pulse, large doses of 10 to 20 μg/pulse, for 17 to 20 days, or starting from the 5th day of the menstrual cycle, intramuscular injection of 50 μg daily for 7 to 10 consecutive days.

(5) Bromocriptine: Suitable for patients with anovulation and hyperprolactinemia. Bromocriptine 1.25 mg, twice a day. If there are no side effects, change to 2.5 mg, twice a day after one week. Generally, ovulation can occur when PRL drops to normal after 3 to 4 weeks of medication.

Medication is a method to treat infertility caused by endocrine disorders. Women can choose this treatment method with confidence. It has a good effect in improving female infertility, and the medication will not cause any harm to the female body. Therefore, when women choose, they can follow the doctor's advice.