Disease causes of hypothalamic amenorrhea

Hypothalamic amenorrhea is a serious threat to women, because once this disease occurs, women will have to have their periods early, which poses a threat to their bodies. Therefore, many women in this situation want to know the specific cause of hypothalamic amenorrhea. In order for you to understand it as soon as possible, please take a look at the answer below.

Causes of Disease

Causes of hypothalamic amenorrhea 1. Mental and nervous factors Mental stress, fear, anxiety, environmental changes, regional migration, and cold stimulation, etc. can all lead to amenorrhea. Due to various stimuli from inside and outside the body, dysfunction between the central nervous system and the hypothalamus is caused, which affects the function of the pituitary gland. Among them, luteinizing hormone (LH) is most easily affected, causing ovulation dysfunction. When the degree of inhibition is aggravated and follicle-stimulating hormone (FSH) is affected, follicle development is impaired and amenorrhea occurs.

Causes of hypothalamic amenorrhea 2. Intracranial organic lesions such as prolactinoma, craniopharyngioma, pinealoma, thalamic tumor, third ventricle tumor, etc.; congenital malformations (hamartomas); inflammation (such as acute leptomeningitis and chronic granulomatous lesions - tuberculous meningitis); sarcoidosis, xanthomas and histiocytosis, etc.; vascular damage (such as hemorrhage, infarction, ischemia, capillary hyperplasia and fat embolism, etc.); trauma, degeneration, porphyria, Wernicke's syndrome (cerebral hemorrhage and necrotizing lesions caused by vitamin B deficiency); all of the above lesions can lead to hypothalamic dysfunction and cause amenorrhea.

Causes of hypothalamic amenorrhea 3. Malnutrition caused by chronic wasting diseases such as chronic liver and kidney diseases, tuberculosis, severe anemia, and gastrointestinal dysfunction can affect the function of the anterior pituitary and the sensitivity of the endometrium to sex hormones through the hypothalamus. Also, nutritional deficiencies may affect the synthesis and secretion of GnH by the anterior pituitary gland, leading to amenorrhea.

Causes of hypothalamic amenorrhea 4. Dystrophia adiposo-genital

Due to the lesions of the hypothalamus and its surrounding tissues, the neurohumoral connection between the hypothalamus and the pituitary gland is abnormal, resulting in obesity, amenorrhea, incomplete development of reproductive organs and secondary sexual characteristics, diabetes insipidus, and incomplete or reduced intellectual development.

Causes of hypothalamic amenorrhea 5. Drug effects. For example, a small number of women develop secondary amenorrhea after using contraceptives, which is mainly caused by temporary inhibition of GnRH, thereby inhibiting the normal cyclical secretion of pituitary FSH and LH. In addition, drugs such as reserpine, chlorpromazine, and α-methyldopa can also cause amenorrhea and galactorrhea.

Causes of hypothalamic amenorrhea 6. Lactational amenorrhea syndrome is due to the decrease in the secretion of hypothalamic prolactin release inhibitory factor (PIF), which leads to increased secretion of pituitary prolactin (PRL) and lactation. Because PRL can competitively inhibit ovarian GnH receptors, it leads to amenorrhea and forms amenorrhea-galactorrhea syndrome.

Causes of hypothalamic amenorrhea 7. Young women with polycystic ovaries, amenorrhea, infertility, hirsutism, obesity, and polycystic and enlarged ovaries.

Causes of hypothalamic amenorrhea 8. Other endocrine gland diseases such as hypothyroidism or hyperthyroidism, adrenocortical hypofunction or hyperfunction, and diabetes can affect the secretion of pituitary GnH through the hypothalamus and cause amenorrhea. In adrenal hyperplasia syndrome, increased androgen production causes amenorrhea.

The above content has given a detailed explanation and introduction to the cause of hypothalamic amenorrhea. If you encounter this situation, do not ignore it. You must have a specific understanding of the above content, and then go to a regular hospital for a comprehensive examination, and then carry out targeted treatment or conditioning to normalize your menstruation as soon as possible.