Causes of PCOS

The ovaries are very important for female friends. If there is a problem with the ovaries of female friends, it will pose a serious threat to their physical health. Therefore, female friends must take good care of their ovaries in daily life. One of the symptoms that ovaries are prone to is polycystic ovary syndrome. We must understand the cause of polycystic ovary syndrome.

The cause of PCOS is still unclear and the pathological mechanisms involved are very complex. It is generally believed to be related to dysfunction of the hypothalamus-pituitary-ovarian axis, adrenal dysfunction, genetics, metabolism and other factors.

1. Genetics

PCOS is an autosomal dominant, X-linked (sex-linked) inheritance, or a disease caused by gene mutation. The chromosome karyotype of most patients is 46,XX, and some patients show chromosome aberration or mosaicism such as 46,XX/45,XO/46,XX/46,XXq and 46,XXq.

2. Adrenarche hypothesis

PCOS originates from prepubertal adrenal disease, that is, when subjected to strong stress stimulation, the zona reticularis secretes too much androgen, which is converted into estrogen outside the gonads, feedback-induced disturbances in the GnRH-GnH release rhythm of the HP axis and an increase in the LH/FSH ratio, which subsequently causes increased ovarian androgen production, that is, the adrenal glands and ovaries jointly secrete more androgen, leading to hyperandrogenemia. Hyperandrogenism causes thickening of the ovarian capsule fibrosis, inhibits follicular development, and causes ovarian cystic enlargement and chronic anovulation.

Traditional Chinese medicine believes that this disease is mainly caused by kidney deficiency, phlegm and dampness, qi stagnation and blood stasis, damp heat in the liver meridians, etc., which lead to dysfunction of the kidney-tiangui-chongren-uterus axis, resulting in amenorrhea and infertility.

In the above article, we introduced the importance of ovaries to female friends. Female friends must pay attention to the health of their ovaries in daily life. Polycystic ovary syndrome is a common ovarian disease. We have introduced the causes of polycystic ovary syndrome in detail above.