What is the disease of protein in female urine

The biggest harm of proteinuria is to erode kidney function, which makes the kidney function suffer more and more damage. Long-term proteinuria can immediately cause uremia. Therefore, patients must pay great attention to it. So what is the reason for high urine protein in women? What are the effects?

Proteinuria is generally caused by impaired kidney function, which is common in cerebral ischemic nephropathy caused by renal tubular damage, renal artery stenosis or abnormalities in the perinephric anatomical structure, leading to renal damage and thus proteinuria. On the other hand, long-term hyperuricemia is also the cause of high urine protein, which can also damage renal function and cause mild proteinuria, but generally there is an abnormal increase in blood uric acid, accompanied by the main manifestations of gout, and significant renal atrophy on one side is rare, so the increase in blood uric acid caused by reduced kidney function should be eliminated. Therefore, you should go to the hospital for the following tests to find out the cause of the disease and facilitate further treatment.

High urine protein can cause the occurrence of many diseases, so what are the common diseases of high urine protein? Please see the following introduction: Quantitative increase of 24-hour urine protein is more common in the following diseases: hypertension and chronic kidney disease. Acute nephritis, chronic nephritis, nephrotic syndrome, pyelonephritis, lupus erythematosus, renal tuberculosis, kidney stones, renal artery sclerosis, etc. Blood renal circulation system obstruction. Such as hematoma, anemia, heart failure, etc. Supplement other symptoms. Such as shock, dehydration, infection, poisoning, sepsis and organ transplantation.

What are the effects of long-term high urine protein in women?

1. Mesangial toxicity of proteinuria: In the physical model of renal failure, the accumulation of serum protein in the renal tubular mesangium can be observed. The accumulation of this macromolecular substance in the mesangial area can cause mesangial cell damage and further lead to tubular sclerosis.

2. Changes in tubular cell biology caused by proteinuria: Many chronic kidney diseases with proteinuria have excessive cell proliferation, which means a maladaptive response and leads to renal failure.

3. Proteinuria aggravates the lack of oxygen in the tubular interstitial space: The metabolism and digestion of proteinuria require additional energy, which can lead to insufficient oxygen in the tubular cells and even cause damage to the tubular cells.

4. The toxic effects of proteinuria on proximal tubular cells: When proteinuria occurs, the amount of protein entering the tubular squamous cells increases, which increases the specificity of lysosomes, prompting proteins to form lysosomes and overflow into the tubular cytoplasm. The subsequent cell damage can stimulate inflammation and scarring.

Based on the above introduction, I believe everyone has a certain understanding and hope to be able to help you.