What does sialidase negative mean?

Vaginitis is a common gynecological disease among women. There are many types of vaginitis, so examining female secretions is an important way to identify the type of vaginitis. Checking the neuraminidase in female secretions can determine the balance of beneficial bacteria in the female vagina. It has important reference significance for the diagnosis of bacterial vaginal diseases. What does it mean when the neuraminidase test is negative for bacterial vaginal infection?

Sialic acid plays a key role in the growth and reproduction of bacteria and their interaction with cells. Some bacteria cannot produce sialic acid themselves, so they metabolize sialic acid enzymes to obtain sialic acid. Gardnerella vaginalis and some Pseudomonas aeruginosa, two of the beneficial bacteria in the vagina, cannot produce sialic acid, so they contain sialidase in their secretions. If a large amount of neuraminidase is detected in female secretions, it means that the beneficial bacteria in the vagina are out of balance and too many pathogens are transplanting and multiplying in the female vagina. Therefore, by testing the neuraminidase in female secretions, the microbalance of beneficial bacteria in the vagina can be determined. If the sialidase test is negative, it means that the beneficial bacteria in the vagina are in a balanced state. Can eliminate symptoms of bacterial infection in the vagina.

Bacterial infection of vaginal disease is different from other vaginitis. Other vaginitis have the clinical medical characteristics of vaginitis space-occupying lesions, while bacterial infection of vaginal disease is a vaginal disease characterized by non-inflammatory space-occupying lesions. Nearly half of the patients generally have no symptoms, and symptomatic patients have increased leucorrhea with fishy and foul odor as clinical symptoms. Some are accompanied by symptoms such as vulvar itching. Bacterial infection of vaginal diseases is mainly caused by the imbalance of beneficial bacteria in the female vagina, which leads to the proliferation of Gardnerella and some Pseudomonas aeruginosa in the vagina. Bacterial infection of vaginal disease is caused by the imbalance of beneficial bacteria in the female vagina. Therefore, bacterial infection of vaginal disease is often combined with other vaginal diseases, such as Trichomonas vaginitis, candidal vaginitis, etc.

A negative neuraminidase test does not rule out the possibility of infection with other specific vaginitis. In the absence of other inflammation, a negative neuraminidase test indicates a balance of beneficial bacteria in the vagina. In the daily maintenance of hygiene and sanitation, we must also be careful not to artificially disrupt this balance. For example, using cleaning fluid to wash the vagina can easily lead to an imbalance of beneficial vaginal bacteria, which in turn can easily lead to the breeding of pathogens. Therefore, it is sufficient to clean the vulva normally.