Pregnant women with elevated leucine aminopeptidase

Pregnant women with abnormally high leucine aminopeptidase results should also keep themselves in a good mood. If they have already shown some symptoms, they should go for a more detailed examination, because this is also related to the health of the fetus in their belly, so it is particularly important. In addition, older mothers are more likely to experience this phenomenon, and they should get corresponding treatment as soon as it occurs.

Abnormal results: This enzyme is widely distributed in various tissues of the human body, with the highest content in the liver, pancreas, gallbladder, kidney, small intestine and uterine muscle layer. The activity of this enzyme increases in pancreatic cancer, with a positive rate of 100%. When the activity of this enzyme is normal, pancreatic cancer can be ruled out, but the activity of this enzyme may also increase in hepatobiliary diseases. Therefore, the clinical application value of this enzyme is similar to that of ALP, but the activity of this enzyme is normal in bone cancer. In addition, the activity of this enzyme gradually increases after 2 months of normal pregnancy and then decreases after delivery. This point should be taken into account when judging the results.

Urinary LAP activity is highest when toxic substances or diseases affect the proximal tubules, which are rich in LAP. LAP increases when the permeability of the glomerular basement membrane increases, tubular epithelial cells are damaged, drug-induced toxic nephropathy occurs, and renal tumors occur. Increased urinary LAP after tumor treatment indicates tumor recurrence. An analysis of various renal cases revealed that LAP had the highest positivity rate.

Auxiliary diagnosis of liver and gallbladder diseases or analysis of kidney damage in people who need examination.

Possible diseases with high results:

Pancreatic cancer, drug-induced liver disease in the elderly.

Leucine aminotransferase is widely present in various tissues of the human body, with the liver, pancreas, gallbladder, small intestine, uterus, and muscles being the most abundant. It is also distributed in the duodenum, serum, and urine. Clinically, the determination of serum leucine aminotransferase is of certain significance in the diagnosis and treatment evaluation of hepatobiliary diseases.

In primary liver cancer, LAP is significantly elevated. The experimental results all show that serum LAP activity is elevated in various liver diseases, and the degree of increase is from high to low: liver cancer, cholestatic hepatitis, acute hepatitis, and cirrhosis. Similar results were obtained, and it was pointed out that normal LAP activity does not rule out the possibility of liver cancer, because the LAP activity of patients with liver cancer may be normal. When measuring other liver enzyme abnormalities in patients, LAP activity should be tested, especially when other liver functions are normal. After excluding diseases such as cholestasis and obstructive jaundice, the possibility of liver cancer should be considered.