Normal progesterone level at 48 days of pregnancy

Female friends are in a dangerous period when they are 48 days pregnant. They need to rest assured to take care of the fetus to avoid some unstable fetal position. At this time, they also need to check their progesterone levels. This is also very important. If the progesterone level is not normal, it will cause some problems and even threaten miscarriage, which is a very critical situation.

1. In the second half of the menstrual cycle, it promotes the growth of endometrial glands, uterine congestion, and endometrial thickening to prepare for the implantation of the fertilized egg. It also reduces the excitability of the uterus during pregnancy, inhibits its activity, relaxes smooth muscles, and allows the embryo to grow safely.

2. Working together with estrogen, it promotes the development of mammary lobules and glands, allowing the breasts to fully develop and prepare for lactation.

3. It closes the cervix, reduces and thickens the mucus, and makes it difficult for sperm to penetrate; in large doses, it has a negative feedback effect on the hypothalamus, inhibiting the secretion of pituitary gonadotropin and producing an ovulation-inhibiting effect.

4. After ovulation, based on the action of hormones, the endometrium continues to thicken and become congested, the glands proliferate and branch, and the proliferative phase turns into the secretory phase, which is beneficial to the implantation of the fertilized egg and the development of the embryo.

5. Inhibit uterine contractions and reduce the uterus' sensitivity to oxytocin, allowing the fetus to grow safely.

6. Competitively antagonizes aldosterone, thereby promoting the excretion of Na and Cl and causing diuresis.

Progesterone has a mild effect of increasing body temperature in normal women, so the basal body temperature in the luteal phase of the menstrual cycle is higher than that in the follicular phase.

1. (1) Threatened abortion: Generally 20 mg per day. After pain and bleeding stop, reduce to 10 mg per day. (2) For patients with a history of recurrent miscarriage: 5-10 mg each time, 2-3 times a week, starting from the beginning of pregnancy, and continuing until the fourth month of pregnancy. (3) Dysfunctional uterine bleeding: Take the drug in the second half of the menstrual cycle, 10 mg per day, for 5 to 10 days. If menstruation occurs during medication, the drug should be stopped immediately. (4) Amenorrhea: Patients with amenorrhea should first undergo a progesterone test: administer 10 mg per day for 5 days and observe whether menstruation occurs after stopping the drug. If effective, 10 mg per day can be given 8 to 10 days before the expected menstrual period for a total of 6 to 8 days.

Premenstrual syndrome: Use progesterone injection 10-20 mg starting 12 days before the expected menstruation for 10 consecutive days. Use progesterone oil injection, 50 mg per day for primiparas and 100 mg per day for multiparas, starting 12 days before menstruation until the onset of menstruation.

2. Vaginal administration: same as oral administration.

3. Rectal administration: Treatment of premenstrual syndrome: Use progesterone suppositories to administer rectum, the dose is 200-800 mg, starting 12 days before menstruation until the onset of menstruation.

3. Progesterone test: 20 mg is injected intramuscularly once a day for 3 to 5 consecutive days. It can be used to (1) understand the cause of amenorrhea: withdrawal bleeding 3 to 7 days after stopping the drug is positive, indicating that the endometrium has been affected by a certain level of estrogen and is exfoliated in response to progesterone; no withdrawal bleeding after 7 days of stopping the drug is negative, indicating that the estrogen level in the body is low and therefore does not respond to progesterone; (2) It can be used as an auxiliary test for early pregnancy: for women suspected of early pregnancy, withdrawal bleeding 3 to 7 days after stopping the drug can rule out pregnancy; no withdrawal bleeding after 7 days of stopping the drug, the possibility of early pregnancy is very high.