How much progesterone is pregnant?

Don't think that checking whether you are pregnant or not, through B-ultrasound or uterine examination, there is also a test of progesterone levels. The level of progesterone indicates that a woman may be pregnant, so when you go to the hospital for a check-up, the progesterone test is a must. Don't think it is unnecessary.

Reference value

The reference values ​​of progesterone in normal women's menstrual cycle are as follows:

Follicular phase: early 0.7±0.1ng/ml; late 0.4±0.1ng/ml

Ovulation period: 1.6±0.2ng/ml

Luteal phase: early 11.6±1.5ng/ml; mid-phase 22.5±1.5ng/ml; late 5.7±1.1ng/ml.

Clinical Application

1. Monitor ovulation: blood progesterone level >15.6nmol/L indicates ovulation. If the progesterone level is consistent with ovulation and the patient has infertility without other reasons, B-type ultrasound examination is necessary to observe the follicular development and ovulation process to exclude luteinized unruptured follicle syndrome (LUFS). When using ovulation-inducing drugs, the blood progesterone level can be used to observe the ovulation-inducing effect. If multiple ovulation occurs and multiple corpora lutea are produced, the blood progesterone level may increase. Primary or secondary amenorrhea, anovulatory menstruation or anovulatory dysfunctional uterine bleeding, polycystic ovary syndrome, oral contraceptives or long-term use of GnRH agonists can all reduce progesterone levels.

2. Understand the function of the corpus luteum: If the blood progesterone level during the luteal phase is lower than the physiological value, it indicates insufficient corpus luteum function; if the blood progesterone level is still higher than the physiological level 4-5 days after menstruation, it indicates incomplete atrophy of the corpus luteum.

3. Understand the status of pregnancy: After ovulation, if the egg is fertilized, the corpus luteum continues to secrete progesterone. Starting from the 7th week of pregnancy, the placenta secretes progesterone in an amount that exceeds the corpus luteum of the ovary. When placental function declines during pregnancy, progesterone levels in the blood decrease. In case of ectopic pregnancy, the progesterone level is low. If the progesterone level is >78.0nmol/L (25ng/ml), ectopic pregnancy can be basically ruled out. If the single progesterone level is ≤15.6nmol/L (5ng/ml), it indicates a stillbirth. During threatened miscarriage, if the progesterone level shows a downward trend, miscarriage may occur. The amount of urinary pregnanediol excretion during pregnancy varies greatly among individuals, making it difficult to estimate placental function, so it is rarely used clinically.

4. Monitoring of progesterone replacement therapy: After removal of the luteal side ovary in early pregnancy, plasma progesterone levels should be monitored when using natural progesterone replacement therapy.

Influence

1. Endometrium: Progesterone mainly promotes the secretion changes of the endometrium to prepare for the implantation of the fertilized egg.

2. Fallopian tube: Progesterone also promotes secretory changes in the lining of the fallopian tube mucosa, which is related to the nutrition required for the fertilized egg to pass through the fallopian tube a few days before implantation in the uterus.

3. Breast: Progesterone promotes the development of breast lobules and breast alveoli. However, progesterone alone will not cause the breasts to secrete milk. Milk is produced only when there is a large amount of prolactin.

4. Progesterone can also cause the basal body temperature to rise.

5. Immunity: During implantation and pregnancy, progesterone will cause a decrease in the mother's immune response and thin the protective mucus of the cervix.

6. Blood sugar: Progesterone secreted by the placenta will increase the mother's blood sugar, ultimately leading to increased nutrient intake by the fetus.