6 abnormal manifestations of female hormones

When the human body is in a healthy state, the internal environment regulated by various balancing functions is stable. Such as acid-base balance, water-oil balance, sex hormones are substances responsible for regulating the human body environment to maintain a balanced and stable state of the human body's internal environment. There are two types of sex hormones. One is androgen, which is secreted by male animals and men. The other is estrogen, which is secreted by female animals and women. The role of hormones cannot be underestimated. If hormone secretion is abnormal, it will cause abnormalities in the normal life activities of the human body. Here are six abnormal manifestations of female hormones:

Six sex hormones:

The six-item hormone test (six-item sex hormone test and six-item reproductive hormone test) is a routine examination of the female reproductive system.

There is no complete and unified gynecological endocrine hormone measurement value in China. Moreover, due to the different sources of various reagents, measurement methods, data calculations, and units used, even for the same hormone sample, the results obtained by different laboratories are not exactly the same.

Chinese name: Six items of sex hormones

Category: Sexual Medicine

Objective: To understand endocrine

Method: Laboratory test

Purpose:

By measuring the levels of sex hormones, we can understand the female endocrine function and diagnose diseases related to endocrine disorders. The six commonly used sex hormones are follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P), testosterone (T), and prolactin (PRL), which basically meet the needs of clinicians for screening for endocrine disorders and general understanding of physiological functions.

The six-item sex hormone test has many tests that can detect many diseases. Therefore, as a common examination item, the six-item sex hormone test is a commonly used examination method for patients with endocrine disorders. Through the six-item sex hormone test, it can be determined whether the patient has endocrine diseases, and then the treatment method can be determined according to the test results.

Inspection method

The inspection items are different and the attention methods are also different. The inspection content can be a full check or a single item check.

1. To check estrogen, progesterone, and follicle-stimulating hormone, 2 ml is required for each test, also after venous serum separation.

2. To check testosterone, 2 ml of venous serum is drawn. The commonly used method is radioimmunoassay, which can be measured after the serum is separated.

3. Prolactin should be checked on an empty stomach, with serum drawn around 9 a.m.

4. Check luteinizing hormone. Although it is also a radioimmunoassay test, because luteinizing hormone is secreted in a pulsed manner, it is best to collect samples 3-4 times within 1 hour and then mix them together for measurement, which is more accurate.

Check time

The best time to check endocrine system is 3-5 days after menstruation. This period belongs to the early follicular stage and can reflect the functional status of the ovaries. However, for those who have not had their menstruation for a long time and are eager to know the test results, they can have the test at any time. The time will be taken as the time before menstruation, and the results will refer to the test results of the luteal phase.

The most accurate result is obtained by having a fasting blood test at 9 a.m. on the 3rd to 5th day after the onset of menstruation. For those who are infertile or have amenorrhea, or have not had menstruation for a long time, the examination can be done at any time, but it is best to do it on an empty stomach.

As long as men do not do strenuous exercise and lead a regular life, they can check at any time on an empty stomach between 8 and 11 a.m.

Check content

1. Testosterone (T): 50% of testosterone in women is converted from peripheral androstenedione, about 25% is secreted by the adrenal cortex, and only 25% comes from the ovaries. The main function is to promote the development of the clitoris, labia and mons pubis. It has an antagonistic effect on estrogen and has a certain impact on systemic metabolism. The normal concentration of T in female blood is 0.7～3.1nmol/L. High blood T levels are called hypertestosterone, which can cause infertility. When suffering from polycystic ovary syndrome, the blood T value also increases. Based on clinical manifestations, other hormones can be measured if necessary.

2. Estradiol (E2): Secreted by the ovarian follicles, its main function is to promote the transition of the endometrium into the proliferative phase and promote the development of female secondary sexual characteristics. The concentration of blood E2 is 48-521 pmol/L in the preovulatory period, 70-1835 pmol/L in the ovulatory period, and 272-793 pmol/L in the postovulatory period. Low values ​​are seen in ovarian dysfunction, premature ovarian failure, and Sheehan's syndrome.

3. Progesterone (P): Secreted by the corpus luteum of the ovary, its main function is to promote the transition of the endometrium from the proliferative phase to the secretory phase. The blood P concentration is 0-4.8 nmol/L before ovulation and 7.6-97.6 nmol/L in the late ovulation period. Low blood P values ​​in the late ovulation period are seen in luteal insufficiency, ovulatory dysfunctional uterine bleeding, etc.

4. Luteinizing hormone (LH): A glycoprotein hormone secreted by the alkaliphilic cells of the anterior pituitary gland. It mainly promotes ovulation. Under the synergistic action of FSH, it forms a corpus luteum and secretes progesterone. The concentration of blood LH is 2-15mIU/ml in the preovulatory period, 30-100mIU/ml in the ovulatory period, and 4-10mIU/ml in the postovulatory period. The normal value during the non-ovulation period is generally 5 to 25 mIU/ml. A level lower than 5mIU/ml indicates gonadotropin insufficiency, which is seen in Sheehan's syndrome. If high FSH is accompanied by high LH, ovarian failure is very certain and no other tests are necessary. LH/FSH≥3 is one of the bases for diagnosing polycystic ovary syndrome.

5. Prolactin (PRL): It is secreted by the lactating trophoblast, one of the eosinophilic cells in the anterior pituitary gland. It is a simple protein hormone whose main function is to promote breast hyperplasia, milk production and milk discharge. During the non-lactation period, the normal value of blood PRL is 0.08-0.92nmol/L. A level higher than 1.0nmol/L is called hyperprolactinemia. Excessive prolactin can inhibit the secretion of FSH and LH, inhibit ovarian function, and inhibit ovulation.

6. Follicle-stimulating hormone (FSH): A glycoprotein hormone secreted by the alkaliphilic cells of the anterior pituitary gland. Its main function is to promote the development and maturation of ovarian follicles. The concentration of blood FSH is 1.5-10mIU/ml in the pre-ovulation period, 8-20mIU/ml in the ovulation period, and 2-10mIU/ml in the post-ovulation period. Generally, 5 to 40 mIU/ml is considered normal. Low FSH values ​​are seen during estrogen-progestin therapy, Sheehan's syndrome, etc. High FSH levels are seen in premature ovarian failure, ovarian insensitivity syndrome, primary amenorrhea, etc.