Multiple papilloma of the esophagus

When treating any disease, you cannot choose the treatment method at will. You must first conduct various physical examinations, so that you can understand the cause and symptoms of the disease. This will help you choose the treatment method and control your own disease. Choosing a treatment method based on your own description will not have any effect on improving the disease. So what is the cause of esophageal papilloma? Many people are not clear about it.

Causes of multiple papilloma of the esophagus:

1. Mucosal damage

Gastroesophageal reflux, esophagitis, hiatal hernia, mechanical operation, etc. often cause esophageal papilloma. Esophageal papilloma is common in the distal 1/3 of the esophagus, which is most severely affected by these lesions. Esophageal papilloma has been reported to occur as a result of endoscopic injury, chronic esophageal foreign body impaction, repeated dilation of a narrowed esophagus with a bougie, and surgical trauma. Many esophageal papilloma pathological examinations show evidence of inflammation.

2. Human papillomavirus (HPV) infection

HPV has a high affinity for human squamous epithelium. Some people have found evidence of HPV infection in the hyperplastic esophageal mucosa. However, the HPV detection rates in esophageal papilloma reported by different authors are inconsistent, and some authors report that HPV is negative. Therefore, the exact relationship between HPV and esophageal papilloma needs further study.

3. Genetic factors

Some people believe that esophageal papilloma is related to genetic factors. For example, congenital skin diseases and Gohze syndrome may be associated with esophageal papilloma. Patients with abnormal karyotypes and O-raf-1 gene deletions may have multiple polyps of the gastrointestinal tract, including esophageal papilloma.

4. The result of multiple factors

Currently, most people believe that esophageal papilloma is the result of the combined action of multiple factors, namely the presence of harmful chemicals and chronic irritation, combined with HPV infection, the two of which act synergistically. This view is accepted by most people. However, the exact pathogenesis needs further study.

After understanding the cause of esophageal papilloma, the treatment of esophageal papilloma also needs a long time. This type of disease is relatively complicated, and after suffering from such a disease, the patient will have obvious physical discomfort. At this time, the patient needs to actively cooperate with the doctor's treatment method to alleviate his or her discomfort.