What is the normal level of estradiol on the second day of menstruation?

I believe that most women are relatively unfamiliar with the term "normal estradiol value on the second day of menstruation". In fact, this is not very strange. It is an uncommon word in itself. It is mainly due to women's lack of knowledge of medical knowledge. Since we have talked about this topic today, let us take you to understand what the normal value of estradiol is on the second day of menstruation. Female friends should always pay attention to this issue.

The study and discussion of perimenopause was an important breakthrough in the medical field - revealing that perimenopausal syndrome is caused by hormone deficiency and can be treated and prevented. The more important significance lies in preventing long-term complications such as osteoporosis, cardiovascular and cerebrovascular diseases, Alzheimer's disease, cancer, etc. that appear about 10 to 15 years after menopause, which seriously affect the quality of life of the elderly and increase the burden on families and society.

Estrogen is mainly derived from the follicular theca cells and granulosa cells. During follicular development, LH first stimulates the follicular membrane to secrete testosterone, which is then converted into estradiol by granulosa cells under the stimulation of FSH, which is the "dual-cell dual-gonadotropin action mode." In addition, it is also secreted by the adrenal cortex, placenta and testicles of male animals. The definition of estrogen here is estradiol, which is the active estrogen in women of childbearing age. The wave-like cyclical changes of 40-400pg/ml give women fertility, reaching 2000pg/ml during pregnancy. Its certain basal secretion (50pg/ml) maintains the normal metabolism of various tissue cells and the stability of the internal environment. The estrogen that decreases sharply and is lacking in menopausal women is also estradiol (0-20pg/ml).

Why then have women for decades supplemented their estrogen with pregnant mare's estrogen (Premarin, also called conjugated estrogen) instead of estradiol, which is what they lack? This is because oral estradiol cannot be utilized (90% is broken down by gastric acid and intestinal microorganisms, and the 10% absorbed is converted into estrogen in the liver). It was discovered by chance 80 years ago that estrogen extracted from pregnant mare's urine has 10% of the activity of estradiol. Oral estradiol is the estrogen that the body really needs. It can relieve women's menopausal symptoms such as hot flashes and sweating, and has therefore become popular. Over time, it has become synonymous with estrogen. In fact, what the ovaries secrete and what menopausal women lack is estradiol, not estrone. Estradiol is the hormone that women cannot live without throughout their lives.

Through the experts' explanation, everyone has a deep understanding of the normal estradiol value on the second day of menstruation. Whether its value is normal or not has a very big impact on women's health. In other words, if women find that this value is abnormal, they should check whether they have entered menopause, and intervention treatment is necessary at this time.