Adequate dietary intake of manganese may reduce the risk of venous thromboembolism by regulating body weight and inflammation

Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most common vascular disease after acute myocardial infarction and stroke, with approximately 10 million new cases of VTE each year worldwide. Therefore, identifying more modifiable risk factors to strengthen primary prevention of VTE has important clinical value and public health significance.

Manganese (Mn) is an essential trace mineral element for the human body, and its main source is dietary intake. Manganese is involved in a series of physiological and pathological processes related to blood coagulation and vascular injury, including oxidative stress, platelet aggregation, activation of coagulation factors, and endothelial cell dysfunction. However, to date, the prospective association between dietary manganese intake and VTE risk and the potential mechanistic pathways remain unclear.

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In response to the above clinical problems, a recent study published in the journal Thrombosis and Haemostasis found that dietary manganese intake was negatively correlated with the risk of VTE, and this negative correlation was mainly mediated by obesity, inflammatory biomarkers, and red blood cell distribution width . Professor Qin Xianhui from the National Clinical Research Center for Kidney Diseases, Nanfang Hospital, Southern Medical University is the corresponding author of the article, and Master's student Huang Yu and Doctoral student Zhang Yanjun are co-first authors.

The study included 202,507 middle-aged and elderly participants from the UK Biobank who had complete dietary data and were free of venous thromboembolism at baseline. Detailed dietary intake was collected using a 24-hour dietary assessment questionnaire, and the total energy and various nutrient intakes of each subject were calculated based on the UK Nutrition Database food composition tables.

During a median follow-up of 11.6 years, 4750 (2.3%) participants developed VTE. Overall, an increase of 1 mg/day in dietary manganese intake was associated with a significant 8% reduction in the risk of VTE, 7% in the risk of DVT, and 9% in the risk of PE (Figure 1).

Figure 1 Association between dietary manganese intake and the risk of VTE (A), DVT (B) and PE (C)

In addition, BMI, waist circumference, C-reactive protein, white blood cell count, red blood cell distribution width, and physical activity significantly mediated the negative correlation between dietary manganese intake and the risk of VTE, with the mediation proportions being 36.0%, 36.5%, 4.3%, 4.2%, 1.6%, and 1.6%, respectively (Figure 2).

Figure 2 The mediating effect of obesity and inflammation

In conclusion, our study suggests that adequate dietary manganese intake can reduce the risk of venous thromboembolism by regulating body weight and inflammation . Our findings once again highlight the important role of nutrition in vascular diseases.

There are thousands of health strategies, but eating well is the most important. Reasonable diet and scientific nutrition are the cornerstone and core of effectively promoting group health and achieving active health.

Information Point - Risk Factors for Deep Vein Thrombosis

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References:

Huang Y, Zhang Y, Yang S, Xiang H, Zhou C, Ye Z, Liu M, He P, Zhang Y, Gan X, Qin X. Association and Pathways between Dietary Manganese Intake and Incident Venous Thromboembolism. Thromb Haemost . 2023 Dec 27.

Editor | Zhang Yanjun, Huang Yu, Xianghao

Audit | Qin Xianhui