The treatment of nephrotic syndrome is not as fast as it should be. Remember to take it easy.

There is an old saying that goes, "Disease comes like a mountain falling, and goes away like pulling a thread." This is the most vivid description for patients with nephrotic syndrome. When patients with nephrotic syndrome get sick, they are very aggressive, but the treatment process is very long. They take a lot of medicine every day, but the reduction of urine protein is very slow. After a long time, patients are anxious. Is there a better, faster and more thorough treatment method?

Patient Lao Li was diagnosed with nephrotic syndrome 8 months ago. A renal biopsy confirmed membranous nephropathy. After six months of conventional treatment, there was no significant reduction in urine protein. Lao Li was anxious and found out about a private clinic that was said to be famous for treating kidney disease. He called for consultation. The other party was very enthusiastic and welcomed him to see a doctor, guaranteeing that he would be cured in two or three months. Lao Li finally saw the hope of "cure" and collected tens of thousands of yuan to go to this private clinic. More than two months later, Lao Li's kidney disease did not improve, but his kidney function worsened. His blood creatinine rose to about 900 micromoles/liter, and his money was gone. Lao Li realized that he had been deceived, but it was too late. There are too many such bloody lessons among the patients we see in our daily work.

It is particularly important to emphasize that nephrotic syndrome is a group of syndromes with different causes and pathological types, and the treatment methods and effects are also very different. All patients diagnosed with the disease should go to regular medical institutions to receive comprehensive treatment from nephrology specialists. Do not seek medical treatment indiscriminately when you are sick, listen to false advertisements, quack doctors and medical frauds, which will delay your treatment and even lead to loss of both your life and money.

Before introducing the treatment of nephrotic syndrome , it should be pointed out that the treatment must be carried out under the guidance of a nephrologist in a regular hospital, otherwise the condition may worsen or even cause serious adverse reactions.

Glucocorticoids, which suppress immune and inflammatory responses, are commonly known as hormones. The general principles for their use are: start with a sufficient dose, reduce the dose slowly, and maintain the dose for a long time.

0 1: The efficacy of initial adequate hormone therapy for nephrotic syndrome is related to the dose. For newly diagnosed cases, the initial dose of treatment must be sufficient to quickly relieve the condition.

0 2: The dosage should be reduced slowly. The dosage can be gradually reduced after the urine protein disappears and stabilizes. It should be emphasized that the dosage should be reduced slowly and it is forbidden to reduce the dosage arbitrarily.

0 3: To maintain the effect, you need to reduce the dosage according to the above method. When the dosage is reduced to a low dosage (about 10 mg/day), it should be taken for another half a year. Usually, the adverse reactions of this low dosage of hormone are not serious.

Cytotoxic drugs and other immunosuppressants

This type of drug is generally not used as the first choice or sole treatment. Due to its complicated usage, it needs to be used under the guidance of a nephrologist, so it will not be described in detail here.

Symptomatic treatment

0 1: Diuresis and swelling reduction There are many types of diuretics commonly used in nephrotic syndrome, and the drug should be selected according to the condition. For patients with severe hypoproteinemia who do not respond well to diuretics, human albumin or plasma infusion can be considered to improve the diuretic effect.

0 2: Anti-infection treatment If infection exists, sensitive antibiotics should be given to prepare for the use of immunosuppressants such as hormones, and care should be taken to choose antibiotics that cause less damage to the kidneys.

0 3: Reduce urinary protein It has been confirmed that angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) have a definite effect on protecting the kidneys, delaying the deterioration of renal function and reducing urinary protein.

04: Antihypertensive treatment The higher the blood pressure, the more harmful it is to the kidneys. Generally, patients with nephrotic syndrome should try to keep their blood pressure below 125/75 mmHg.

05: Lipid-lowering treatment In the past, not enough attention was paid to the application of lipid-lowering measures in nephrotic syndrome. In recent years, more and more attention has been paid to the application of lipid-lowering drugs, such as lovastatin, simvastatin, etc., which are generally taken before bedtime.

Traditional Chinese Medicine Treatment

It is generally recommended to use it in combination with the above-mentioned western medicines. Tripterygium wilfordii total glycosides (Tripterygium wilfordii polyglycosides) tablets are a traditional Chinese medicine preparation that is widely used in clinical practice. It has the effect of reducing urine protein and can be used in combination with hormones.

summary

Once nephrotic syndrome is diagnosed, patients should have confidence and be prepared for a "protracted battle". During treatment, regular checkups and timely communication with doctors should be conducted to determine the efficacy and complications. In addition, laboratory test reports and outpatient medical records should be kept in case of need to observe the condition and adjust the treatment plan. Let us work together to win the protracted battle against "nephrotic syndrome"!