Clinical research | Clinical treatment of diabetic patients, stem cell transplantation treatment satisfaction rate 80%

Clinical researchers from the Department of Endocrinology at the Third Medical Center of the PLA General Hospital (formerly the General Hospital of the Armed Police Force) conducted a study on stem cell transplantation for diabetic patients and found that on the basis of satisfactory blood sugar control, the dose of oral hypoglycemic drugs was reduced by 30% or the dose of insulin was reduced by 30%. The results showed that 64 patients were satisfied with blood sugar control, with a satisfaction rate of 80%.

Diabetes is one of the major chronic diseases that currently threatens human health and seriously affects the health and quality of life of patients.

Currently, there are about 450 million diabetics in the world, and the incidence rate is increasing year by year. Therefore, exploring a safe and reliable diabetes treatment has become a public health issue of global concern.

Treatments for diabetes include lifestyle changes, oral hypoglycemic drugs, insulin replacement therapy, and pancreatic transplantation, but these therapies cannot achieve the desired therapeutic effect. Therefore, it is urgent to explore alternative methods for treating diabetes and maintaining the therapeutic effect. Mesenchymal stem cells (MSCs) are widely present in various organs and tissues such as bone marrow, fat, and umbilical cord. They also have multidirectional differentiation potential, can secrete a variety of substances such as growth factors and cytokines, participate in the body's regulation of immune responses, and promote angiogenesis. In addition, MSCs have been widely used in the treatment and research of various diseases because of their low immunogenicity and few ethical controversies.

In recent years, stem cell transplantation has been considered a potential method for treating diabetes. Mesenchymal stem cells (MSC) are widely favored by scholars due to their wide sources, low tumorigenicity, and few ethical controversies.

80 cases of diabetes, 80% satisfaction rate of stem cell transplantation treatment. Clinical researchers from the Department of Endocrinology of the Third Medical Center of the PLA General Hospital (formerly the General Hospital of the Armed Police Force) conducted a clinical study on stem cell transplantation for the treatment of diabetic patients. The research report was published in an industry journal with the title "Experiences of 6-month follow-up of diabetic patients after stem cell transplantation treatment."

This study selected 80 patients with diabetes (100 ml of bone marrow was collected from all selected patients through the posterior superior iliac spine, and stem cells were extracted and injected into the pancreatic tissue through the pancreatic artery). There were 58 males and 22 females, ranging in age from 10 to 80 years, with an average age of (42.2±12.2) years. The course of disease was 2 months to 30 years, with an average course of disease of (8.0±1.2) years. Twenty patients took oral hypoglycemic drugs, 6 took insulin injections, 53 took oral hypoglycemic drugs combined with insulin injections, and 1 patient controlled the disease by diet and exercise alone.

Observation of the effect of stem cell therapy (1) Standards for satisfactory blood sugar control: According to the IDF guidelines, the standards for satisfactory blood sugar control are: fasting blood sugar ≤ 7.0mmol/L, 2h postprandial blood sugar ≤ 10.0mmol/L, and glycosylated hemoglobin < 7.0%. (2) Standards for effective stem cell therapy: On the basis of satisfactory blood sugar control, the dose of oral hypoglycemic drugs is reduced by 30% or the dose of insulin is reduced by 30%. Results: 64 cases were satisfied with blood sugar control, with a satisfaction rate of 80%.

The study pointed out that stem cell transplantation therapy is to inject a certain number of extracted stem cells into the pancreatic tissue through the femoral artery. Under the induction of the pancreatic tissue microenvironment, the stem cells can differentiate and proliferate into islet-like cells, replace the damaged pancreatic B cells to synthesize insulin and other functions, and play a role in treating diabetes. However, the injected stem cells must go through a differentiation and proliferation stage before they can play a role, so the patient's daily living environment and behavior for a period of time after treatment will have positive and negative effects on the efficacy.

In addition, in terms of nursing measures, the report recommends that patients need to adjust their attitudes and look at the results objectively. Patients have too high expectations for stem cell technology and hope to recover to the level of healthy people after treatment. However, when the recovery situation is somewhat different from the expected level, there may be more serious disappointment, inferiority, anxiety, depression and other emotions, and they often show refusal to cooperate with treatment, which makes the condition worse. Therefore, during the patient's recovery period, preoperative and postoperative psychological guidance should be provided, and the patient's negative emotions should be discovered and guided in time so that the patient can properly deal with various problems that arise during the postoperative recovery period. Disclaimer: The content comes from the Internet and the copyright belongs to the original author. This article is popular science knowledge and is only for the purpose of information exchange. It is not for commercial use. If it involves the content of the work, copyright and other issues, please contact us to delete it.

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