Understand in one picture: How to administer rabies vaccine, serum, protein, and monoclonal antibody!

On September 16, 2023, the National Center for Disease Control and Prevention issued a notice on the promulgation of the Rabies Exposure Prevention and Treatment Work Specifications (2023 Edition). In the new version of the "Rabies Exposure Prevention and Treatment Work Specifications (2023 Edition)", the "rabies vaccine" vaccination procedures (especially the vaccination procedures after re-exposure) and the types of "animal immune preparations" were updated.

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In fact, I personally think that the most important updates are nothing more than two points:

1. The immunization procedure after "re-exposure" has been clarified: 2 injections on days 0 and 3 are sufficient!

*Previously, various domestic documents required that a maximum of 5 vaccinations be given according to the interval between the last vaccination. I have criticized this situation for a long time, but the documents followed in China have not been in line with international standards, and there is no reliable evidence to support such a vaccination procedure.

2. Added application recommendations for "monoclonal antibodies": including "anti-rabies serum 40IU/kg", "rabies immunoglobulin (20IU/kg)", "single-component monoclonal antibody (20IU/kg, maximum 40IU/kg)", and "two-component monoclonal antibody (0.3mg/kg)" four options!

*Rabies monoclonal antibody is a passive immunization agent recommended by the World Health Organization. Public information shows that my country has previously approved the marketing of the single-component "Olmutivir Monoclonal Antibody", and another two-component "Zemelovir Mazoprevir Monoclonal Antibody" is also in the investment promotion stage.

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Based on the latest information, I used a table to make a detailed division of the application of vaccines and passive immunization preparations in different situations in the "Rabies Exposure Prevention and Treatment Work Specifications (2023 Edition)" and the "Technical Guidelines for Rabies Prevention and Control (2016 Edition)". Medical care staff engaged in related work can choose corresponding management methods and disposal measures based on this table.

Finally, I would like to emphasize that it is "highly not recommended" for ordinary people to judge the risks or choose the treatment methods on their own. It must be judged by professionals! Don't be afraid of rabies! But don't underestimate rabies! Don't think that you can accurately judge and deal with the situation after exposure without professional background!

May the world be free of epidemics

=Pill=

Disclaimer: This article was created out of personal interest, only to help more ordinary people have a clearer understanding of vaccines. The content and views do not represent any organization, unit, or institution, and it has not accepted any form of sponsorship. All pictures are from public online platforms. If the content is incorrect, please do more self-criticism (not).