Learn more! What is the relationship between intravenous human immunoglobulin and vaccination?

When your baby is vaccinated, the doctor will always ask: Has your child taken any medicine recently? At this time, mothers may have a little doubt in their minds, which drugs will affect vaccination? Common drugs that affect vaccination include glucocorticoids, antibiotics, immunosuppressants, cytotoxic drugs and antibodies such as intravenous human immunoglobulin. Today, the pharmacist will take you to understand the impact of intravenous human immunoglobulin on vaccination.

What kind of medicine is intravenous human immunoglobulin?

Intravenous human immunoglobulin is a combination of immunoglobulins separated and extracted from normal human plasma. It contains broad-spectrum IgG antibodies against viruses, bacteria or other pathogens. The unique type and unique antibody of immunoglobulin can form a complex immune network, which has the dual therapeutic effects of immune replacement and immune regulation. After intravenous injection, it can quickly increase the IgG level in the recipient's blood and enhance the body's anti-infection ability and immune regulation function.

In a word, human immunoglobulin helps the body improve or regulate immunity.

What types of illnesses in children are treated with IV human immune globulin?

Children are often a group with relatively low immunity, and when they suffer from the following diseases, they need supportive treatment with human immunoglobulin, such as Kawasaki disease, idiopathic thrombocytopenic purpura, severe infection and neonatal sepsis, primary immunoglobulin deficiency, rheumatoid arthritis, autoimmune-mediated simple red cell aplasia, hemophilia, etc.

What should I pay attention to when vaccinating my baby after he has used intravenous human immunoglobulin?

Vaccines are divided into inactivated vaccines and attenuated vaccines. I wonder if mothers know which ones are inactivated and which ones are attenuated? What is the relationship between inactivated or attenuated vaccines and intravenous human immunoglobulin?

1. Inactivated vaccines are easy to understand. After obtaining the virus, it is inactivated by high temperature or chemical reagents, leaving only the external characteristics, and then inoculated into the human body. The immune system will recognize the characteristics of the dead virus, and when it encounters the same live virus in the future, it will activate specific immunity and eliminate the virus. Inactivated vaccines include: rabies vaccine, inactivated polio vaccine, inactivated hepatitis A vaccine, inactivated Japanese encephalitis vaccine, 13-valent pneumococcal conjugate vaccine, 23-valent pneumococcal polysaccharide vaccine, Haemophilus influenzae conjugate vaccine (Hib), acellular diphtheria, pertussis and tetanus vaccine, pertussis vaccine, group A meningococcal polysaccharide vaccine, group A+C meningococcal polysaccharide vaccine, group A+C meningococcal conjugate vaccine, etc.

1. Attenuated vaccines are more complicated. After obtaining the virus, it is necessary to artificially cultivate it to mutate it, and then select the strains with less toxicity. It is required that there is no reaction or only a slight reaction after contact with the human body to make a vaccine. Therefore, this attenuated vaccine is actually a "live virus", but it is less toxic and only causes an immune response without causing disease. Attenuated vaccines include: BCG vaccine, varicella vaccine, measles vaccine, leprosy vaccine, measles-mumps-rubella vaccine, oral rotavirus vaccine, bivalent attenuated live polio vaccine, Japanese encephalitis attenuated vaccine (there is also an inactivated vaccine), hepatitis A attenuated vaccine (there is also an inactivated vaccine), etc.
2. After the baby has used intravenous human immunoglobulin, there will still be a large amount of antibodies in the body for 3 to 4 weeks. The specific antibodies will interfere with the production of antibodies by the attenuated vaccine, resulting in vaccination failure. It is recommended that babies who have used intravenous human immunoglobulin should be vaccinated with certain live attenuated vaccines, such as polio, leprosy, rubella, mumps and varicella virus vaccines, 3 months later. In addition, if intravenous human immunoglobulin is used within 14 days after vaccination, the vaccine should be re-administered 3 months after the last infusion of this product.

It is important to emphasize that for babies who have received intravenous human immunoglobulin, inactivated vaccines must be used for vaccination within 3 months. If inactivated vaccines are not available, the interval between attenuated vaccines must be noted, and certain live attenuated vaccines can only be administered after 3 months.