What causes corpus luteum deficiency?

Many mothers who are preparing for pregnancy have not been able to conceive for many years. When they go to the hospital for a check-up, they often hear that the disease is corpus luteum insufficiency. So what is corpus luteum insufficiency and what causes it? For women with insufficient corpus luteum, the corpus progesterone begins to shrink 4 to 5 days after ovulation, and the second half of the menstrual period is also relatively shortened. After ovulation, progesterone metabolizes estrogen again. Generally, 8 to 10 days after ovulation, if the egg is not fertilized, the corpus luteum begins to shrink.

Usually, during this menstrual cycle, estrogen is relatively insufficient and the uterine wall is underdeveloped, so sperm and egg fertilization cannot occur. Luteal insufficiency does not necessarily mean that the estrogen and estrogens metabolized by the corpus luteum are insufficient, and the metabolic changes in the uterine wall are insufficient.

Recurrent spontaneous abortion can be caused by insufficient corpus luteum. During the first trimester of pregnancy, corpus luteum insufficiency is critical. During this stage, progesterone secretes high-quality growth hormone, which can make the endometrium proliferate and hypertrophy, providing a favorable environment for test tube embryo implantation.

It is generally believed that corpus luteum insufficiency is related to the following factors:

The ovarian fluid contains follicle-stimulating hormone and estradiol. If the secretion of follicle-stimulating hormone is insufficient during the follicular phase, the levels of the first two components will be too high, resulting in corpus luteum insufficiency.

During the female ovulation period, insufficient lutein peak in the blood is also the main manifestation of luteal insufficiency.

During the follicular phase, if progesterone or its single pulse secretion is insufficient, luteal insufficiency may also occur.

Abnormalities in steroid hormone protein kinase in the cells of the loaded uterine wall may lead to a weak response to growth hormone in the metabolism of progesterone, which also leads to corpus luteum deficiency and abnormal endometrial development.

Ladies should know that if the corpus luteum is insufficient, a normal pregnancy cannot be maintained. In the second half of the menstrual cycle and the first three months of pregnancy, the use of estrogen suppositories in the vagina can improve luteal insufficiency to a certain extent. If you are a pregnant woman, you must avoid artificial estrogen. If you use the drug unreasonably in the early stages of pregnancy, it may harm the fetus.