How to judge whether pregnant women have high bile acid

Many women suffer from minor illnesses after pregnancy, so what are the symptoms of high bile acid in pregnant women? High bile acid in pregnant women has little effect on the pregnant women themselves, but it has a great impact on the fetus, so expectant mothers must pay great attention to it. The following is a detailed explanation for everyone:

What are the symptoms of high bile acid in pregnant women?

1. Itchy skin

High levels of glycocholic acid are associated with intrahepatic cholestasis of pregnancy. The clinical symptoms of obstetric cholestasis are itchy skin, and the itching is more severe at night, causing fatigue and insomnia. The itching usually starts on the palms of the hands and soles of the feet and may then spread all over the body. Some pregnant women cannot stand the itchiness and keep scratching their skin until it bleeds. Rarely, sick pregnant women may develop jaundice. The itching symptoms will completely disappear within a week or two after the pregnant woman gives birth.

2. Blood cell CG levels gradually increase with the number of weeks of pregnancy

Glycocholic acid is the most important bile acid component in blood cells in late pregnancy. In normal pregnancy, the CG level of pregnant women's blood cells gradually increases with the number of weeks of pregnancy. The CG value of full-term pregnancy is 30%-60% higher than that of non-pregnant women. The glycocholic acid content of normal human blood cells is 1.3±0.8mg/L, ranging from 0.4-2.98mg/L.

Causes and harms of high bile acid in pregnant women

The high bile acid level in pregnant women is caused by changes in estrogen levels, and pregnant women are prone to intrahepatic cholestasis. Due to the increase of estrogen and estradiol in pregnant women, the smoothness and peristalsis of the bile duct are inhibited, resulting in poor bile drainage and bile stagnation. The total bilirubin and bile acids in the bile are returned to the blood through the hepatic sinusoids and are circulated to the whole body of the pregnant woman and fetus. Excessive total bilirubin can pass through the fetal blood-brain barrier to cause "kernicterus" and affect brain development. Its main harm is to increase the rate of premature babies, intrauterine distress and intrauterine mortality of fetuses, and increase the occurrence of postpartum hemorrhage in pregnant women. Intrahepatic cholestasis of pregnancy can cause intrauterine hypoxia and fetal death in severe cases. Generally, the patient should be hospitalized for strict monitoring of the fetus. The pregnancy can be intervened according to the maturity of the fetus and the condition of bile stasis. Generally, treatment can be continued until 37 weeks. High bile acid is caused by the relaxation of the gallbladder smooth muscle by the effect of estrogen, which leads to poor bile metabolism. Chinese herbal medicine has basically no side effects. Pregnant women can do exercises to improve their condition. If the patient is suitable, it is better to see a doctor.