Letrozole tablets for successful pregnancy

Some female friends have made a lot of efforts to prepare for pregnancy, but they have not been able to get pregnant successfully. If there is an obstruction in ovulation function, they need to take ovulation-inducing drugs, among which letrozole tablets are currently a commonly used ovulation-inducing drug. Metrol tablets are easily absorbed by the gastrointestinal tract, and the drug effect is exerted quickly. Therefore, after symptomatic treatment, the effect of promoting ovulation is still very good, and the chance of successful pregnancy for women is very high.

The mechanism of its ovulation-promoting effect mainly has two aspects:

The load is on the nerve center. Letrozole tablets block the conversion of androgens to estrogen by inhibiting the specificity of aromatase, reducing the level of estrogen in the body, thereby eliminating the negative feedback effect of estrogen on the hypothalamus and pituitary gland, increasing the secretion of endogenous gonadotropin, and promoting the development and ovulation of eggs.

At full term, the increase in the concentration of male hormones in the eggs can cause the uterus and ovaries to present a transient and reversible polycystic ovary (PCO) state, which increases the sensitivity of the eggs to FSH/HMG. At the same time, the androgen in the uterus and ovaries can promote early uterine development. Androgen can promote the proliferation of theca cells and granulosa cells and inhibit their apoptosis, thereby increasing the number of preantral eggs and antral eggs. This effect is mainly maintained through the regulation of androgen protein kinase. Since the expression of androgen protein kinase in granulosa cells of early follicular stage is multiple times higher than that in mature follicles, the expression level of its gene is also higher. The increase in testosterone levels and the increase in insulin-like growth factor Ⅰ (IGF-Ⅰ) in the egg, cooperate with other endocrine and parametabolism factors to enhance the role of FSH in promoting egg recruitment and development.

Letrozole ovulation induction treatment will not increase the fetal malformation rate or affect the development of test tube embryos. However, it is not recommended that women with normal ovulation period should not get pregnant through this method, and they should not blindly buy this kind of medicine through cross-disciplinary methods and take it independently to achieve the purpose of "multiple births". What's more, all drugs have side effects. Therefore, women who have ovulation problems are not recommended to take letrozole tablets to increase the probability of conceiving twins or twins.

The above is a detailed introduction to letrozole tablets for inducing ovulation and pregnancy.

Frequently asked questions

Players should use with caution

For patients with unclear menopausal status, the patient's LH, FSH and/or estradiol levels must be checked before treatment to clarify their menopausal status.

This product should not be used together with other drugs containing estrogen, because estrogen will offset the medicinal value of this product.

This product can reduce the level of estrogen in the blood circulation system. Long-term use may cause a decrease in normal bone density.

For women with osteoporosis or at risk of osteoporosis, they should use a bone density meter to assess their normal bone density before using this product for auxiliary treatment, and regular maintenance is required thereafter.

It is recommended to monitor overall bone health during treatment and, if necessary, at any time to prevent or treat osteoporosis, and patients with problems should be closely monitored.

Renal insufficiency

No creatinine clearance