What are the reasons why ovulation induction does not lead to pregnancy?

In vitro fertilization is in vitro fertilization. Generally, controlled ovulation induction is the key link in producing high-quality oocytes. Ovulation induction should be based on women's response to drugs. The dosage and time of drug use should be adjusted during the ovulation induction process. Women of different ages react differently to drugs. Many people do not understand the reasons why ovulation induction does not lead to pregnancy. What are the reasons why ovulation induction does not lead to pregnancy? Let’s take a look at it next.

1. What are the reasons why ovulation induction does not lead to pregnancy?

1. The key to the ovulation induction process is to grasp the medication time and dosage. Too long or too short a time will affect the overall ovulation induction effect.

2. Estrogen should not be used excessively. Estrogen can promote the secretion of luteinizing hormone, and luteinizing hormone can promote ovulation. Therefore, the use of estrogen can induce ovulation.

3. Avoid complications. The main complication of ovulation induction in in vitro fertilization-embryo transfer (IVF-ET) is ovarian hyperstimulation syndrome. Many patients have poor ovarian function, so they can only choose short-term ovulation induction.

2. Comfort and safety

1. For young women with good ovarian function, in fact, as long as they have 1 to 5 eggs, they can achieve a pregnancy rate of more than 60%. Therefore, mild stimulation and micro-stimulation plans, giving low-dose stimulation, can achieve the same effect as retrieving 15 eggs, which makes the patient comfortable and avoids egg waste.

2. For women with normal ovarian reserve function, a mild stimulation plan is recommended. The dose of ovulation-inducing drugs can be reduced by 1/3, and the target number of eggs is about 5 to 8. This can reduce the stimulation burden on patients and still achieve a good pregnancy rate, with an embryo implantation rate of more than 40%.

3. For women with ovarian dysfunction and low expected pregnancy rate, if mild stimulation does not work, it is recommended to use a micro-stimulation program, with a target number of 2 to 5 eggs. It is better to retrieve eggs several times and wait for the random opportunity of "good eggs" to appear, rather than "killing the chicken to get the eggs"-like stimulation, which hits the ovaries hard and prevents them from turning over.

4. For couples whose husbands have severe oligoasthenozoospermia, or who need testicular and epididymal sperm retrieval, or who need preimplantation genetic diagnosis (PGD), they need relatively more eggs and a correspondingly larger dose of stimulation. The target number of eggs is generally expected to be around 10 to 15.

3. Notes

The design of the target egg number plan and the weighing of the pros and cons and cost-effectiveness require in-depth communication with the patient couple in order to gain their understanding and acceptance. With the in-depth progress of personalized medicine, the target number of eggs for ovulation induction treatment in the future will definitely be customized. Experts will try their best to develop the most suitable stimulation plan for each woman. The success standards and concepts of obtaining a single pregnancy, full-term, live birth, and comfortable in vitro fertilization-embryo transfer (IVF-ET) will become more popular.