Is gamete intrafallopian transfer successful?

GIFT is a new method for treating infertility that was developed after the in vitro fertilization technology. It is relatively simple and has a relatively good success rate. However, GIFT has certain limitations. It requires at least one side of the fallopian tube to be normal and there is no severe abdominal adhesion. Anesthesia is required during the operation.

Gamete intrafallopian transfer, or GIFT. It is a new method developed after the in vitro fertilization technology that is simpler, more economical and has a higher success rate in treating infertility. The gametes, i.e. mature eggs and active sperm, are placed directly into the ampulla of the fallopian tube through laparoscope or a small abdominal incision, so that the sperm and eggs can be fertilized naturally in the normal fallopian tube in the human body. The fertilized egg then migrates to the uterus through the movement of cilia in the fallopian tube wall for implantation and further development.

Operation process

The GIFT operation process is: ovulation induction, egg retrieval, egg culture and semen processing with in vitro fertilization and embryo transfer (test tube baby). First, fully aspirate the bloody ascites at the bottom of the uterine rectum under laparoscopy, then use a transplantation straw to attract the egg and 30 ml of sperm floating fluid, insert the tube through the laparoscope into the fallopian tube 2 cm to 3 cm, and inject the egg and sperm. The best number of eggs to be injected is 4 to 5. More than 2 eggs can be injected into the left and right fallopian tubes. Progesterone should be used starting from the second day after egg collection, 30mg to 50mg per day, for a total of 13 days.

The advantages of GIFT are:

① Closer to the physiological state. Sperm can more easily acquire energy in the fallopian tube than outside the body, so fertilization is easier in the fallopian tube, especially in cases of oligospermia. The fertilized egg develops better in the fallopian tube than in vitro.

②No complicated equipment required.

③The success rate is higher.

Mainly used in the following situations:

① Fallopian tube disease. At least one side of the fallopian tube is unobstructed, or even if it is unobstructed, adhesions on the periphery make it difficult to retrieve the egg.

②Ovulation disorder. Such as luteinized unruptured follicle syndrome.

③Other gynecological diseases, such as endometriosis, cervical lesions, etc.

④ Unexplained infertility and long-term treatment without pregnancy.

⑤ The man has oligospermia or asthenospermia and has undergone three cycles of artificial insemination without pregnancy.