Ovarian overstimulation symptoms

Infertility is a very difficult situation for people to accept, but with the advancement of technology, people have also found ways to deal with this situation. Women can conceive through IVF, but there will be some adverse reactions during IVF. Overstimulation of the ovaries is a common problem for women during IVF. So what are the symptoms of overstimulation of the ovaries?

Symptoms of ovarian hyperstimulation syndrome

The main manifestations of ovarian hyperstimulation syndrome are gastrointestinal discomfort, abdominal distension, dyspnea, oliguria, etc. The patient's bilateral ovaries are enlarged. In severe cases, the cardiopulmonary function is reduced, the liver and kidney function are damaged, pleural effusion, ascites, and even pericardial effusion, adult respiratory distress syndrome, vascular embolism, and even multiple organ failure.

Ovarian hyperstimulation syndrome can be mild, moderate, or severe, depending on clinical and laboratory manifestations.

Mild

Incidence 8-23%;

This usually occurs 7-10 days after HCG injection;

Lower abdominal discomfort, mild abdominal distension and pain, poor appetite;

Ovarian diameter measured by B-ultrasound ≤5cm;

Blood estradiol ≥1500ng/L;

Moderate

The incidence rate is 1-6%;

Obvious lower abdominal distension and pain, nausea, vomiting or diarrhea, increased abdominal circumference, and weight gain ≥ 3KG;

Obvious ascites, small amount of pleural effusion;

The ovaries on both sides are significantly enlarged, reaching 5-10cm in diameter;

Severe

The incidence rate is 0.2-1.8%;

Abdominal distension and pain intensify, ascites increases significantly, can cause breathing difficulties, can not lie down;

Large amounts of pleural effusion and ascites lead to cardiopulmonary dysfunction, hemoconcentration, acute renal failure, etc.

Weight gain ≥ 4.5 kg

Ovarian diameter ≥ 10 cm

How to prevent it

Ovarian hyperstimulation syndrome is an iatrogenic disease. Prevention is the key. Doctors should use ovulation-inducing drugs with caution.

1. Pay attention to high-risk groups, such as younger, thinner patients with a tendency to PCOS.

2. Reduce the initial dose of gonadotropin for high-risk groups, and be very cautious when increasing the dose during superovulation treatment.

3. During the ovulation induction process, the development of follicles, ovarian size, and blood estradiol levels should be closely monitored, and the patient's physical signs should be paid attention to and the hormone dosage should be adjusted in a timely manner.

4. It is recommended to cancel fresh embryo transfer for patients who are prone to overstimulation or have already experienced overstimulation. If pregnancy occurs after embryo transfer, endogenous HCG

The production of OHSS may aggravate OHSS and cause late-onset OHSS.

Patients should understand ovarian hyperstimulation syndrome and take self-prevention measures

1. Pay attention to your symptoms and record your intake and output, abdominal circumference, and weight.

2. Wear high-waisted tight shorts with a tightness of about 2 fingers, and wear them for at least 30-45 days.

3. Appropriate activities: When getting up, turning over, or changing body positions, move slowly, try to avoid bending over, and do not engage in strenuous activities to prevent ovarian torsion and cyst rupture. But you should also exercise appropriately to prevent venous thrombosis.

4. Reasonable diet: drink plenty of water (2000-2500ml/day), eat small meals frequently, eat easily digestible food, and appropriately supplement high-protein food (such as fish and shrimp).

5. If you experience obvious abdominal distension and pain, chest tightness and shortness of breath, a significant decrease in urine volume, unexplained swelling and pain on one side of the limbs, dizziness, headache, blurred vision and other symptoms, you need to go to the hospital as soon as possible.