What does cervical intraepithelial neoplasia grade 3 mean?

Cervical intraepithelial neoplasia (CIN) is a general term for a group of precancerous lesions that are closely related to invasive cervical cancer. It includes cervical intestinal metaplasia and cervical carcinoma in situ, reflecting the continuous development process of cervical cancer, that is, a series of clinical manifestations from cervical intestinal metaplasia (mild, central, severe), central carcinoma in situ, central early invasive cancer, and central invasive cancer. So what does cervical intraepithelial neoplasia grade 3 mean?

Cervical intraepithelial neoplasia grade 3 is a precancerous lesion of the cervix. It may develop into cervical cancer. It is a serious problem to detect and requires surgical treatment, at least cervical conization. If no invasion is found in the postoperative pathology, hysterectomy is not necessary and regular follow-up is sufficient. If subtle invasive cancer is found in the postoperative pathology, total hysterectomy is required.

Cervical intraepithelial neoplasia: The continuous process of a series of precancerous lesions from atypical proliferation of cervical epithelial cells to carcinoma in situ is called cervical intraepithelial neoplasia.

CIN is a group of precancerous lesions closely related to cervical invasive cancer, reflecting the continuous process of cervical cancer occurrence and development, including cervical atypical hyperplasia and cervical carcinoma in situ. CIN can be divided into three grades according to the degree of cell changes and the range of atypia: Grade I is mild intestinal metaplasia, in which atypical cells are limited to 1/3 of the subepithelial tissue; Grade II is mild to moderate intestinal metaplasia, in which atypical cells are mainly located in 1/3 to 2/3 of the subepithelial tissue layer, and the cell optical rotation remains; Grade III is moderate to severe intestinal metaplasia and/or carcinoma in situ, in which the diseased cells basically or completely occupy the epithelial cell layer, accompanied by increased nuclear division phase and decreased optical rotation.

The prognosis of cervical intraepithelial neoplasia is good. After standard treatment, the possibility of further development to cervical cancer can be blocked. HPV vaccine has practical significance in the primary prevention of cervical intraepithelial neoplasia and cervical cancer. The vigorous development of cytological screening, combined with colposcopy and endoscopic puncture biopsy, is conducive to the early detection and early diagnosis of cervical intraepithelial neoplasia.