Cervical intraepithelial neoplasia grade 3

More and more women are suffering from gynecological diseases and should cooperate closely in treatment. Serious gynecological diseases are all caused by mild inflammation, so you should pay more attention to some daily changes in your body, deal with them in time, and seek medical treatment in time. So, what is the cause of grade 3 uterine intraepithelial neoplasia? Let me learn about it together below.

What is cervical intraepithelial neoplasia?

Cervical intraepithelial neoplasia (CIN) is a group of precancerous lesions closely related to cervical invasive cancer, which reflects the continuous process of cervical cancer development. Cervical intraepithelial neoplasia has two different outcomes. One is that the lesion often disappears naturally and rarely develops into invasive cancer; the other is that the lesion has the potential for disease progression and may develop into invasive cancer. Cervical intraepithelial neoplasia often occurs in women of appropriate age, while cervical cancer is common in women over 40 years old.

According to the degree of somatic cell atypia and the extent of epithelial cell invasion, cervical intestinal metaplasia is divided into three degrees (or grades): mild, moderate, and severe.

What is the cause of uterine intraepithelial neoplasia grade 3?

Moderate to severe intestinal metaplasia (or grade III): Somatic cell atypia is obvious and abnormally proliferating somatic cells occupy more than 2/3 of the epithelial cells or reach the cell layer.

Causes of cervical intraepithelial neoplasia

HPV infection is the most important risk source for the occurrence and development of cervical intraepithelial neoplasia. Cervical intraepithelial neoplasia is also related to factors such as chaotic marital life, early marital life, reproductive tract infection, smoking, contraceptives and immunosuppression.

1. HPV infection

More than 90% of cervical intraepithelial neoplasia are caused by HPV infection. HPV infection can cause cell cycle control disorder and produce malignant migration. When HPV infection persists for a long time, it can cause cervical intraepithelial neoplasia under the influence of other factors such as smoking, use of emergency contraception, reproductive tract infection, etc.

2. Uniqueness of cervical histology

The cervical epithelium is composed of squamous epithelium inside the cervix and vagina and columnar epithelium in the endocervical canal. The uniqueness of cervical histology is the pathological basis of cervical intraepithelial neoplasia.