Can pregnant women with blood type O have a second child?

We all know that our blood has types, generally they are type A, type B, type AB and type O. I still remember when I was in school, the teacher said how good O-type blood was and that it was universal blood. At that time, anyone with O-type blood would be proud of it for a while. Later I learned that if a pregnant woman has O-type blood, then if she wants to have a second child, she must have her blood checked with the father, otherwise she is likely to develop AB0 hemolytic disease.

Can pregnant women with blood type O have a second child?

There may not be a problem. You can do a hemolysis test. Please do a good job of pre-pregnancy check-up and preparation.

Treatment of hemolysis in pregnant women with type O blood

1. Light therapy

It is the simplest and most effective way to lower serum bilirubin. When serum bilirubin reaches the phototherapy standard, phototherapy should be performed in time. The phototherapy standards are formulated based on the presence or absence of complications at different gestational ages and at different days of age.

2. Drug treatment. Early application of intravenous immunoglobulin has better clinical effect. Albumin increases the binding of free bilirubin and reduces the occurrence of bilirubin encephalopathy.

3. Blood transfusion.

When the serum bilirubin level reaches the transfusion standard according to different gestational ages and different days of age, transfusion therapy is required. Only severe cases of ABO hemolytic disease require exchange transfusion therapy.

4. Prevent hypoglycemia, hypocalcemia, hypothermia and electrolyte imbalance.

Precautions for pregnant women with blood type O

If a couple's mother is type O and the father is type A, B, or AB, they belong to a high-risk group and should check the antibody titer regularly during pregnancy. The normal value should be greater than 1:64. On the contrary, if it is 1:128 or 1:256, you should be alert to the possibility of hemolysis. If there is any abnormality, you can treat it during pregnancy, take Chinese medicine or get injections under the guidance of a doctor, and it will be within normal values ​​by the time of delivery. If the treatment during pregnancy is not effective, treatment can still be given after the baby is born. If a pregnant woman has experienced repeated miscarriages, neonatal hemolytic disease, early neonatal jaundice, or neonatal anemia, edema, etc., she should suspect blood type incompatibility with the fetus and undergo tests to confirm the diagnosis. If the child's blood type does not match the mother's after birth, early treatment is also required.

Symptoms of hemolytic neonates in pregnant women with type O blood

1. Jaundice is the main symptom of ABO hemolytic disease. Most cases occur 2 to 3 days after birth, and about 1/4 of children develop jaundice within the first day after birth. Similarly, about one-quarter of patients developed severe jaundice [serum total bilirubin above 342 mol/L (20 mg/dl)].

2. Anemia. Patients with ABO hemolytic disease all have anemia to varying degrees, but the degree is generally mild. Severe anemia (hemoglobin below 100g/L) accounts for only about 5%.

In some mild cases of ABO hemolytic disease, the early symptoms may not be severe, but late anemia may occur 2 to 6 weeks after birth, or the anemia may be particularly severe during the "physiological anemia" period 8 to 12 weeks after birth. This is because the antibodies persist and chronic hemolysis occurs. Blood type antibodies can shorten the lifespan of red blood cells. It is reported that the lifespan of red blood cells in this type of children is only about 35 days, and the daily hemoglobin decreases by about 4 times that of normal children in the same period. The destruction of red blood cells increases, and the bone marrow hematopoietic function is physiologically low at this time and cannot effectively compensate, eventually leading to late neonatal anemia.