What is cervical adenocarcinoma? These are the common reasons!

Cervical adenocarcinoma will not have obvious symptoms in the early stages, or may have some symptoms of cervicitis, so it is often mistaken for cervicitis, which may delay the treatment of the disease. Patients with cervical adenocarcinoma will have common symptoms such as vaginal bleeding and increased leucorrhea. In order to avoid serious development of the disease, it is necessary to go to the hospital for scientific examination in time and receive timely treatment after diagnosis.

1. Viral infection (40%):

Biological studies have shown that the occurrence of cervical cancer is closely related to human papillomavirus (HPV) infection. HPV DNA can be detected in both cervical squamous cell carcinoma and adenocarcinoma tissues. The HPV types related to cervical cancer are mainly 16, 18 and 31, but the proportions of HPV types in cervical squamous cell carcinoma and adenocarcinoma are different. HPV16 is the main type in cervical squamous cell carcinoma, and HPV18 only accounts for 5% to 17% of HPV-positive tumors, while HPV18 is the main type in cervical adenocarcinoma, accounting for as high as 34% to 50%, suggesting that HPV 16, 18, especially HPV18, may play an important role in the development of cervical adenocarcinoma.

2. Endocrine disorders (40%):

Some scholars believe that the causes of cervical adenocarcinoma are different from those of cervical squamous cell carcinoma. They believe that the occurrence of adenocarcinoma has little to do with sexual life and childbirth, but may be related to endocrine disorders and the use of exogenous hormones. Cervical adenocarcinoma often occurs in menopause, which is related to the frequent hormone disorders in the body during this period. Microglandular hyperplasia (microg-landular hyperplasis) can be seen in the cervix of women who use progesterone drugs and pregnant women. This is because progesterone stimulates the proliferation of reserve cells under the columnar cells of the endocervical endometrium and differentiates in the direction of glands, indicating that glandular hyperplasia is related to progesterone. Qizilbash, Gallup and others believe that if high-dose progesterone preparations are taken for 10 years or more, the risk of cervical cancer increases. Gallup reported that 28 of 35 cases of cervical adenocarcinoma had received sex hormone preparations, and 3 of them had been treated with combined estrogen and progesterone.

3. Others (10%):

Some people believe that cervical adenocarcinoma has similar characteristics to cervical squamous cell carcinoma, such as early sexual intercourse, disordered sexual life, and multiple sexual partners. It also has similar characteristics to endometrial cancer. The rates of infertility, oligofertility, obesity, hypertension and diabetes are significantly higher than those of cervical squamous cell carcinoma. Some scholars have also noticed the relationship between cervical adenocarcinoma and long-term use of contraceptives. Ireland reported that 8 out of 73 patients with cervical adenocarcinoma had taken contraceptives, and Gallup reported that 5 out of 35 patients with cervical adenocarcinoma had taken contraceptives for 1 to 8 years. Because the number of cases in most materials is small, the causal relationship between contraceptives and cervical adenocarcinoma is difficult to determine, but it is worthy of attention.