What are the reasons for IVF implantation failure?

In vitro fertilization is the choice of many infertile women. After layers of examinations, IVF transplantation is very critical. Usually, there is a high chance of failure in IVF transplantation. This may be due to the woman's old age, failure of ovulation induction, or poor follicle treatment, which can easily lead to failure of IVF transplantation.

Common factors for failure of IVF transplantation

1. Failure of ovulation induction.

The first is the reason for the failure of ovulation induction. Ovulation induction refers to the use of drugs to encourage women to release more eggs at one time. Normal women only release one egg per menstrual cycle. Generally, older women have a weak ovarian reserve, which means that the number of follicles stored in the ovaries is very small.

The rest are almost of poor quality. After ovulation induction, these women ovulate in small quantities and with poor quality, and the success rate is not very high. Some women with premature ovarian failure have low innate reserves and are prone to failure. In addition, for women with polycystic ovary syndrome, due to abnormal follicular development, it is more difficult to induce ovulation, ovarian hyperstimulation is prone to occur, and the success rate is sometimes not high.

For women who are in good health and have a decent ovarian reserve, ovulation induction failure can easily occur if the timing of ovulation induction is not chosen well, or if they become sick, become overly nervous or fatigued during the ovulation induction process. Of course, it cannot be ruled out that the doctor uses inappropriate dosage of medicine or the test tube plan is not comprehensive, which leads to the failure of ovulation induction due to the lack of personalized plan.

2. Egg retrieval failed.

Egg retrieval failure means that after a woman has ovulation induction, she has a certain number of follicles, but the oocytes in the follicles are not successfully extracted. The chance of this happening is very low, about one in a thousand. When the number of follicles is small, the chance of egg retrieval failure is relatively higher. However, if the number of follicles is sufficient, it is rare that they cannot be removed, and the technology in this regard is relatively mature.

There is a condition called "empty follicle syndrome" that can lead to egg retrieval failure. It refers to the situation where, when the number of follicles is moderate and the size is appropriate, the follicles are aspirated according to the principle of egg retrieval about 36 hours after HCG injection, but no eggs are retrieved. The incidence rate is about 0.5%. The cause of empty follicle syndrome is unknown, and some unfortunate patients may experience it repeatedly.

3. Failure to form a fertilized egg.

After the egg is retrieved, it will combine with the male's sperm to form a fertilized egg. Failure in this link is related to the quality of eggs and sperm, which is not easy to predict in advance. If you do not pay attention to improving the quality of eggs and sperm before pregnancy, it may lead to low-grade embryos that are difficult to implant after transplantation.

Generally, couples who fail in this stage have often checked many items for many years but still cannot find the specific cause of infertility. This shows that the reason why they cannot get pregnant is most likely because of the poor quality of eggs or sperm. Chromosome problems are very common, especially for older people.

4. Failure of embryo formation.

The fertilized egg develops into an embryo, and the qualified embryo is transplanted into the mother's body. This step depends on the quality of the fertilized egg. If the fertilized egg is not good, or the quality of the embryo formed is not good, it will lead to failure and the transplant cannot be performed.