Can positive anti-endometrial antibodies be cured?

Positive anti-endometrial antibodies can cause female infertility, so of course you must pay attention to understanding the correct treatment methods. Currently, the treatment for positive anti-endometrial antibodies includes isolation therapy, immunosuppressive therapy, and artificial insemination therapy.

(1) Isolation therapy: Women with sperm alloimmune infertility can use condoms for 3 to 6 months to avoid further stimulation of sperm antigens on the female. After the antibody titer disappears, they can choose sexual intercourse during the ovulation period to hope for conception.

(2) Immunosuppressive therapy: Adrenal cortical hormones can be used to treat immune infertility, such as taking 5 mg of prednisone three times a day two weeks before ovulation. There are also reports of topical vaginal hydrocortisone in the treatment of infertile women with antisperm antibodies in their cervical mucus. The pregnancy rate is reported to be between 20% and 45%.

(3) Intrauterine insemination: When there are sperm antibodies in the cervical mucus that interfere with conception, the husband's semen can be processed in vitro to separate high-quality sperm for intrauterine insemination.

(4) In vitro fertilization and embryo transfer (IVF): If a woman has persistent high titer anti-sperm antibodies in her body, she may be considered for IVF. Some people have reported that the fertilization rate of in vitro fertilization and embryo transfer technology for immunologically infertile people reached 83% and the pregnancy rate reached 33%.

(5) Gamete intrafallopian transfer (GIFT): Nerwe et al. reported a study on 16 men diagnosed with immune infertility and their spouses who underwent gift surgery. Among them, 7 couples (43%) became pregnant. Therefore, this method is considered to be a very effective and safe method.