What causes endometrial thickening?

Endometrial thickening may be a problem of endometrial hyperplasia. What we need to pay attention to is that it has a certain tendency to become cancerous, so we must pay attention to observe and understand the situation, and pay attention to understand the causes. For example, the use of estrogen drugs cannot be blind.

1. The causes of endometrial hyperplasia are not yet very clear, but the following phenomena and facts indicate that long-term estrogen stimulation is the main cause of the disease.

2. Anovulation may occur in adolescent girls, perimenopausal women, or those with a disorder in a certain link of the hypothalamus-pituitary-ovarian axis, polycystic ovary syndrome, etc. The endometrium is continuously affected by estrogen for a longer period of time without the opposition of progesterone and lacks the transformation of the cyclical secretory phase, and is in a state of hyperplasia.

3. In patients receiving postmenopausal estrogen replacement therapy (ERT), it was observed that 20% of women developed endometrial hyperplasia after using estrogen alone for one year.

4. Endometrial hyperplasia can also be observed in postmenopausal patients with advanced breast cancer who have been treated with tamoxifen (TAM) for a long time. Tamoxifen has a weak estrogen-like effect.