What are the new treatments for premature ovarian failure?

Premature ovarian failure has been on the rise in recent years, which is mainly related to the patient's living habits and mood. When premature ovarian failure occurs, it must be treated in a timely manner. There are many ways to treat this disease, and novel treatment methods also have good therapeutic effects.

1. Estrogen treatment of premature ovarian failure

The negative feedback effect of estrogen on the central nervous system can inhibit the secretion of Gn. E can directly act on the ovaries to cause the proliferation of granulosa cells, increase the sensitivity of the ovaries to FSH, and increase the number of LH receptors, thus contributing to the development and maturation of follicles. Currently, E and P sequential therapy, that is, artificial cycle therapy, is mostly used to treat premature ovarian failure. Occasionally, treatment is effective, and most successful pregnancies are the result of this treatment.

2. Surgery for premature ovarian failure

Patients with premature ovarian failure caused by ovarian nutritional deficiency due to ovarian vascular factors should be diagnosed and treated early, and vascular bypass surgery should be performed as soon as possible before the ovarian function is completely lost, such as anastomosing the ovarian artery with the inferior mesenteric artery or renal artery to restore the ovarian blood supply and restore vitality to the ovaries. For those who are in the late stage of premature ovarian failure or have ovaries missing due to various reasons, ovarian transplantation has become a very successful means of treating premature ovarian failure. A small part of another person's ovary can be used to complete female physiological functions.

3. Application of IVF or gamete fallopian tube transfer technology

Egg donation technology has opened up a new way to solve the fertility problems of those with premature ovarian failure. The patient uses estrogen and progesterone to cause the endometrium to undergo secretory phase changes, and the timing must be synchronized with that of the egg donor. The egg donor undergoes ovulation induction treatment, and the mature eggs are removed at the appropriate time. The sperm of the husband of the patient with premature ovarian failure is fertilized with the egg donor's eggs in vitro. The fertilized eggs are then transplanted into the patient's uterine cavity at the appropriate time (gamete fallopian tube transplantation can also be performed), and estrogen and progesterone are appropriately supplemented until about 20 weeks of pregnancy.