Causes of Endometrial Fibrosis

Endometrial fibrosis is a gynecological disease that occurs when the surrounding tissues become fibrotic and agglomerated due to stimulation and changes in their previous shape. This is the result of my simple description. You can get a general idea of ​​what effects endometrial fibrosis has on the body. How to treat this disease? Let’s take a look at the causes of endometrial fibrosis.

A concept

The ectopic endometrium is affected by sex hormones, causing repeated cyclical bleeding, which leads to fibrosis of the tissue around the lesion and finally forms nodules or masses.

2. Clinical manifestations

1. Dysmenorrhea

Dysmenorrhea is the most typical symptom of endometriosis. It can occur before, during, or after your period. In severe stages, the pain is unbearable and increasing the dosage of analgesics may not even be effective. The pain is caused by internal bleeding from endometriosis stimulating local tissue inflammatory response. Endometriosis lesions secrete more prostaglandins, which causes uterine muscle contractions and makes dysmenorrhea more pronounced. After menstruation, bleeding stops and pain is relieved.

2. Abnormal menstruation

It may present as heavy menstruation or irregular menstrual cycles. Most of the menstrual abnormalities are related to the impact of endometriosis on ovarian function. Patients with endometriosis may experience ovarian dysfunction, such as abnormal ovulation.

3. Infertility

Infertility is common in women with endometriosis. Cause: Endometriosis can often cause adhesions around the fallopian tubes, affecting the pickup of oocytes; or ovarian lesions can affect ovulation.

4. Pain during sexual intercourse

Endometriosis in the rectouterine fossa and vaginal rectal septum may cause dyspareunia (deep tenderness) and frequent, painful bowel movements (tenesmus) during menstruation.

5. Others

Bladder irritation symptoms: When endometriosis spreads to the bladder, there will be periodic frequent urination, painful urination, and hematuria. Endometriosis in abdominal wall scars and umbilicus causes periodic local lumps and pain.

Three treatments

(1) Pseudo-pregnancy therapy is the use of powerful progestin contraceptive drugs, which are taken continuously for a long time in larger doses to stop menstruation. The endometrium and ectopic endometrium undergo a pregnancy-like reaction under the action of the drugs, so it is also called pseudo-pregnancy therapy. There are many drugs used for this therapy, and they are still being developed. The main ones for oral administration include progesterone acetate, provira, and nemethicone, while the ones for intramuscular injection include progesterone caproate. This treatment must be continued for at least six months before the ectopic endometrium can stop moving and eventually shrink, thus producing therapeutic effects.

(2) Pseudomenopause therapy In the 1970s and 1980s, foreign countries mainly used a drug called danazol, which is a derivative of androgen and has a good effect. It is also being used in my country, but it has relatively large side effects. Since the 1980s, a drug called goserelin has been widely used abroad. It can strongly suppress the function of the ovaries, making them almost completely ineffective, thereby achieving the purpose of treatment. Moreover, since this drug is a long-acting sustained-release preparation, it only needs to be injected subcutaneously once a month, which is very convenient. This type of drug can cause the endometrium to atrophy similar to that of menopausal women, so it is called pseudomenopause therapy.

After reading the above content, you will have some understanding of the causes and treatment options of endometrial fibrosis. The inconvenience brought by this disease is very distressing, so everyone must try not to get this gynecological disease, pay more attention to the hygiene of your uterus and private parts of the lower body, take more baths, clean the vagina, avoid diseases caused by unhygienic conditions, stay away from gynecological diseases, and embrace a healthy life.