Is it better to have high or low hcg?

Generally speaking, a higher hcg is better. Of course, the most important thing is to see whether it doubles in the later period. Doubling is better, which indicates that the embryo is growing and developing better. hcg is an important part of prenatal examination. If the value is relatively low, it will affect the development of the fetus. It can promote and stimulate the formation of progesterone. We know that progesterone is more important for the development of the fetus. Let's take a look at this aspect.

What is the normal value of hCG?

The normal value of blood hCG is <10μg/L, and the normal value of β-hCG is <3.1μg/L. β-hCG is a part of hCG. Generally, the β-hCG radioimmunoassay value of a normal woman is less than 3.1. If it exceeds 5, the possibility of pregnancy can be considered. If it exceeds 10, pregnancy can be basically confirmed.

The absolute values ​​of serum hCG vary greatly at different stages of pregnancy and between pregnant women. They are not comparable with each other and can only be compared within themselves. During the first 3 months of pregnancy, hCG levels approximately double every 2.2±0.5 days.

hCG values ​​over time

Human chorionic gonadotropin enters the maternal blood after fertilization and proliferates rapidly until the 8th week of pregnancy, then slowly decreases in concentration until the 18th to 20th week, and then remains stable. Generally, an increase in the level of human chorionic gonadotropin to at least 2.5MoM is associated with Down syndrome. However, the actual average level of complete human chorionic gonadotropin in the maternal blood of DS patients is only 1.3MoM, which cannot clearly identify DS patients. The human chorionic gonadotropin-related molecules used for DS examination are free b-hCG and high sugar hCG (H-hCG).

The levels of human chorionic gonadotropin-related molecules are also related to the sex of the fetus. The levels of human chorionic gonadotropin in baby girls are significantly higher than those in baby boys.

Complete human chorionic gonadotropin is produced entirely by the syncytiotrophoblast of the placental chorion. Human chorionic gonadotropin is produced by trophoblast transitional cells and syncytial cells. Human chorionic gonadotropin begins to be secreted 10-14 days after conception.

Function of hCG

1. It has the functions of FSH and LH, maintains the life of the menstrual corpus luteum, and enlarges the menstrual corpus luteum into the corpus luteum of pregnancy;

2. Promote the aromatization of androgens into estrogen and stimulate the formation of progesterone;

3. Inhibit the stimulation of plant lectins on lymphocytes. Human chorionic gonadotropin can be adsorbed on the surface of trophoblast cells to prevent embryonic trophoblast cells from being attacked by maternal lymphocytes;

4. It has LH-like function. Before the fetal pituitary gland secretes LH, it stimulates the fetal testicles to secrete testosterone to promote male sexual differentiation. It can also promote gonadal development, stimulate the activity of interstitial cells in the testicles in men, and increase the secretion of androgen (testosterone). It is of great significance for the treatment of male patients with combined pituitary deficiency. It can not only promote gonadal development and the secretion of male hormones, but also promote the development of secondary sexual characteristics.

5. It can bind to the TSH receptor of maternal thyroid cells and stimulate thyroid activity.