What causes high urine protein in women?

There are two main reasons for high urine protein in the human body, namely physiological and pathological. The so-called pathological reasons usually refer to the high urine protein caused by lesions in the human urinary system. In addition, the human body will be affected by fever, low temperature stimulation or strenuous exercise. Urinary protein is affected. This is the so-called physiological reason. The main reasons for high urine protein in women are as follows.

What causes high urine protein in women?

The biggest harm of proteinuria is that it poisons the kidneys and causes more and more damage to the kidneys. Long-term proteinuria can directly lead to the occurrence of uremia, so patients must pay attention to it. So what is the reason for high proteinuria in women? What are the impacts?

Proteinuria is generally caused by kidney damage, and is more common in ischemic nephropathy caused by glomerular damage, renal artery stenosis or abnormal perinephric anatomical structure, which leads to kidney damage and subsequent proteinuria. On the other hand, long-term hyperuricemia is also the cause of high urine protein. It can also damage the renal interstitium and cause mild proteinuria, but generally the blood uric acid level is abnormally elevated and accompanied by gout symptoms. Unilateral obvious renal atrophy is rare, so the increase in blood uric acid caused by decreased renal function should be ruled out. Therefore, you should go to the hospital for the following examinations to find out the cause of the disease and facilitate further treatment.

High urine protein can cause many diseases. So, what are the common diseases caused by high urine protein? Let’s take a look at the following introduction: Increased 24-hour urine protein is common in the following diseases: ① Kidney disease. Acute nephritis, chronic nephritis, nephrotic syndrome, pyelonephritis, lupus erythematosus, renal tuberculosis, kidney stones, renal artery sclerosis, etc. ② Renal circulation disorder. Such as congestion, anemia, heart failure, etc. ③Other diseases. Such as shock, dehydration, infection, poisoning, leukemia and kidney transplantation.

What are the effects of long-term high urine protein in women?

1. Mesangial toxicity of urinary protein: In the renal failure model, the accumulation of serum protein in the glomerular mesangium can be observed. The aggregation of these macromolecules in the mesangial area can cause mesangial cell damage, thereby producing glomerular sclerosis.

2. Biological changes in tubular cells caused by proteinuria: Many kidney diseases that cause proteinuria have excessive cell proliferation, which represents a non-adaptive response and leads to renal failure.

3. Urinary protein causes aggravation of tubular interstitial hypoxia: Proteinuria requires additional energy to reabsorb and digest a large amount of protein, which can cause tubular cell hypoxia and thus cause tubular cell damage.

4. Toxic effect of urinary protein on proximal tubular cells: When proteinuria occurs, the amount of protein entering the renal tubular epithelial cells increases, which increases the activity of lysosomes, indicating that protein causes lysosomes to overflow into the tubular cytoplasm. The subsequent cell damage can stimulate inflammation and scar formation.