What causes elevated serum prolactin?

High serum prolactin is a relatively serious disease. If it is not effectively treated, it will develop rapidly and cause great harm to the body. Therefore, many patients with this disease want to know specifically what causes this condition? In order for you to get effective treatment as soon as possible and to understand the cause, take a look at the following introduction.

1. Primary hypothyroidism: When the thyroid function is hypo, the secretion of TRH and TSH increases, causing the level of prolactin in the blood to rise, resulting in hyperprolactinemia.

2. Chronic renal failure: Serum prolactin is excreted through the kidneys. When renal function is poor, serum prolactin rises.

3. The most common is pituitary prolactinoma: among patients visiting the gynecological endocrinology clinic, about 1/3 of those suffering from hyperprolactinemia and amenorrhea suffer from pituitary tumors.

4. Adrenal insufficiency: Glucocorticoids can inhibit the transcription and release of prolactin genes. There are case reports of patients with renal insufficiency developing hyperprolactinemia, whose blood prolactin levels returned to normal after glucocorticoid replacement therapy.

5. Empty sella syndrome: Due to congenital abnormalities or defects in the sella turcica septum caused by trauma or surgery, the arachnoid membrane forms a herniation and enters the sella turcica, compressing the pituitary gland and pituitary stalk. Since the transport of dopamine is affected, hyperprolactinemia occurs.

6. Hypothalamic pituitary stalk disease: The mechanism by which hypothalamic disease causes elevated serum prolactin is believed to be due to a disorder in the production or transport of PIF. If the pituitary tumor compresses the pituitary stalk, it may also affect the transport of PIF.

7. Idiopathic hyperprolactinemia: The cause has not been identified and no pituitary tumor has been found. The functional abnormal increase in prolactin is called idiopathic hyperprolactinemia. In some patients, pituitary microadenomas may be too small to be detected yet.

What is the reason for increased serum prolactin? In order for patients with this disease to receive effective treatment, some of the causes are introduced above. So after understanding the above introduction, in order for you to receive effective treatment and recovery as soon as possible, you can choose a regular hospital as soon as possible and get rid of this disease through treatment, so that you can have a higher quality of life.