Causes of uterine squamous cell hyperplasia

I did not have a very correct understanding of tumor diseases, because I thought that tumors were generally keratinous tumors. Because they occur in different parts of the body, no matter where they occur, as long as they are removed, they can be cured. However, this is an incorrect understanding. Uterine squamous cell atypical hyperplasia is also a tumor and can also lead to cervical cancer. What are the causes of it?

The discussion on the correct classification of cervical squamous cell atypical hyperplasia has not yet been concluded. The reason is that the pathogenesis of cervical cancer cannot be accurately determined not only morphologically but also biologically. A commonality among all discussions is that this is a class of lesions with different healing and degeneration potentials. Koss believes that about one in ten untreated dysplasias will develop into cervical cancer. However, it must be noted that mild atypical hyperplasia cannot always be distinguished with certainty from reactive or regenerative processes, and human papillomavirus (HPV) infection has an impact on the prognosis of atypical hyperplasia. It is generally agreed that not every atypical hyperplasia is the beginning of an irreversible neoplastic process.

According to this view, cervical intraepithelial neoplasia (CIN) is a one-way street, as CIN groups 1-3 are considered a biological continuum and are at risk for transitional treatment (eg, conization in the case of mild dysplasia). The advantage of CIN classification is that CIN 3 groups are morphologically and biologically classified as "severe atypical hyperplasia" and "carcinoma in situ".

In 1990, Richart proposed a more simplified classification, dividing it into "low-grade" and "high-grade" lesions, which became the basis of the Bethesda cytology diagnostic system. Based on this introduction, non-dysplastic lesions associated with HPV have been referred to as “low-grade” neoplastic lesions, and moderate dysplasia has been included in the category of “high-grade” neoplastic lesions.

After the above introduction, I have a comprehensive understanding of uterine squamous epithelial atypical hyperplasia. It cannot be completely cured by resection. It has certain complexity and recurrence. To achieve the goal of complete cure, different treatment methods such as drug treatment and surgical treatment can be adopted.