Causes of thickening of the uterine lining

Anyone with a little biological knowledge knows that the uterus is the organ that produces menstruation and nurtures the fetus. It is located in the center of the female pelvic cavity. Many girls will experience thickening of the endometrium during their postnatal development process. Many people do not know the reasons for the thickening of the endometrium, nor do they know what impact the thickening of the endometrium will have on physical health? Today, the editor will take you to understand the reasons for the thickening of the endometrium, hoping to be helpful to everyone.

Reason 1. Endogenous estrogen (one of the reasons for the thickening of the endometrium)

(1) Anovulation: Anovulation may occur in adolescent girls, perimenopausal women, disorders in certain links of the hypothalamus-pituitary-ovarian axis, polycystic ovary syndrome, etc., causing the endometrium to be continuously affected by estrogen for a long time without progesterone to counteract it, lacking the transformation of the cyclical secretory phase, and being in a state of hyperplasia for a long time. In patients with atypical endometrial hyperplasia under the age of 40, except for focal atypical hyperplasia, more than 80% of the other endometrium has no secretory phase; 70% of the basal body temperature measurement results are monophasic. Therefore, most patients do not ovulate. (2) Obesity: In obese women, androstenedione secreted by the adrenal glands is converted into estrone by aromatase in adipose tissue. The more adipose tissue there is, the stronger the conversion capacity and the higher the estrone level in the plasma, thus causing a persistent estrogenic effect. (3) Endocrine functional tumors: Endocrine functional tumors are rare tumors, but in research statistics, endocrine functional tumors account for 7.5%. The gonadotropin function of the pituitary gland is abnormal, and ovarian granulosa cell tumor is also a tumor that continuously secretes estrogen.

Reason 2. Exogenous estrogen

(1) Estrogen replacement therapy (ERT): During the perimenopause or postmenopause period, due to estrogen deficiency, there are menopausal syndromes, and there may also be osteoporosis, abnormal blood lipid metabolism, cardiovascular changes, and even changes in brain cell activity. Therefore, ERT has gradually been widely used and has achieved good results. However, ERT, with estrogen alone, can stimulate endometrial hyperplasia. One year of estrogen use alone can cause endometrial hyperplasia in 20% of women (Woodruff 1994). The use of ERT is often continuous for years, or even for a lifetime. If it is not combined with progestins for a long time, severe endometrial hyperplasia or even endometrial cancer will occur. (2) Application of tamoxifen: Tamoxifen (TAM) has an anti-estrogen effect and is therefore used in postmenopausal patients with advanced breast cancer. Under conditions of low estrogen, TAM has a weak estrogen-like effect, so long-term use of TAM can also cause endometrial hyperplasia.

The reasons for the thickening of the endometrium include both internal factors of the body during the growth process and external influences. No matter what the reason is, everyone should take it seriously. The uterus is an important symbol of the female body, so its health is very important. You must take good care of your body.