Good sleep reduces risk of acute kidney injury

In modern society, problems such as lack of sleep and insomnia are becoming more and more common, and these problems are closely related to health. Previous studies have shown that various sleep behaviors, such as excessive/short sleep time, excessive daytime sleepiness, insomnia and snoring, are all related to decreased renal function. In addition, sleep is multifaceted, and sleep patterns mainly include five sleep behaviors: sleep time, sleep type (early/late sleep type), insomnia, snoring, and excessive daytime sleepiness. Various sleep behaviors affect each other and jointly affect physical health. However, it is not clear whether there is an association between the above-mentioned different sleep behaviors and comprehensive sleep patterns and the risk of acute kidney injury .

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In response to the above-mentioned clinical problems, the National Clinical Research Center for Kidney Diseases, Nanfang Hospital, Southern Medical University, conducted relevant work to explore the prospective association between five sleep behaviors and sleep patterns and new-onset acute kidney injury in the general population . The research results were recently published in the journal Sleep Health . The study found that healthy sleep patterns, adequate sleep time (7-8 hours/day), early bedtime, never or rarely insomnia, and no frequent daytime sleepiness are independently associated with a reduced risk of new-onset acute kidney injury. Professor Qin Xianhui of the National Clinical Research Center for Kidney Diseases, Nanfang Hospital, Southern Medical University is the corresponding author of the article, and graduate student Gan Xiaoqin and physician He Panpan are co-first authors.

The study used data from the UK Biobank, which included more than 370,000 participants with a baseline glomerular filtration rate ≥30 mL/min/1.73 m² and no acute kidney injury. A healthy sleep pattern is defined as: sleeping 7-8 hours a day, going to bed early, never or rarely suffering from insomnia, not snoring, and no frequent daytime sleepiness . The healthy sleep score of each participant was calculated based on the five factors of the healthy sleep pattern mentioned above. Each factor was scored 1 point if it met the standard. The higher the score, the better the overall sleep quality (Figure 1).

Figure 1 Calculation of healthy sleep score

During the 12-year follow-up, 14,492 (3.9%) participants developed acute kidney injury. Overall, maintaining a healthy sleep pattern was significantly inversely associated with the risk of new acute kidney injury; each 1-point increase in the healthy sleep score significantly reduced the risk of acute kidney injury by 5%.

At the same time, the genetic risk score for acute kidney injury had no significant modifying effect on the association between healthy sleep score and the risk of acute kidney injury; that is, maintaining a healthy sleep pattern would have the same degree of benefit regardless of whether the genetic risk for acute kidney injury was high or low .

In addition, sleeping 7-8 hours/day (compared with sleeping <7 hours or ≥9 hours), going to bed early (compared with going to bed late), no insomnia or rarely insomnia (compared with sometimes/often insomnia), and no frequent daytime sleepiness (compared with frequent/always daytime sleepiness) were significantly associated with a lower risk of acute kidney injury.

This study comprehensively evaluated the relationship between sleep patterns and the risk of acute kidney injury, emphasizing the important clinical value of maintaining healthy sleep in preventing acute kidney injury. This article reminds everyone again:

Have a good sleep,

It’s really important!

References:

Gan X, He P, Ye Z , Zhou C, Liu M, Yang S, Zhang Y, Zhang Y, Qin

Editor | Gan Xiaoqin, He Panpan, Huang Yu

Audit | Qin Xianhui