GADD45 family: Superheroes who fight against aging diseases and step out from behind the scenes

Currently, there is only one drug targeting GADD45 under development worldwide - KES-0001, which is used to treat two serious blood diseases, multiple myeloma and diffuse large B-cell lymphoma.

The drug was originally developed at Imperial College London, while Kesios Therapeutics Ltd. is responsible for further development.

The GADD45 family consists of three members: GADD45A, GADD45B, and GADD45G. These three members are like the guardians of the cellular world. They are found in various tissues of the human body, silently regulating the occurrence of tumors, metabolic balance, and cell self-protection. As scientists conduct in-depth research on the GADD45 family, we have a better understanding of these tiny but powerful proteins.

Recently, the latest research results of Xavier Palomer and other scholars, GADD45A: With or without you, were published in Med Research Reviews. The research team discussed in depth the key member of the GADD45 family, GADD45A. The article explored its role in cancer, metabolism, neurodegenerative diseases and cardiovascular diseases, and how it can serve as a potential target for the treatment of these diseases.

The paper analyzes existing research results through literature review and explores the function and regulatory mechanism of GADD45A in different disease contexts. It is like a "superhero" in the story, guarding our health.

The figure above shows the regulatory mechanism of GADD45A and its multifunctional role in biological processes such as cell survival, apoptosis, and cell cycle.

Tumor nemesis

In the world of tumors, GADD45A is like a fearless warrior that can identify and stop the "bad guys" who try to disrupt the order of cells. When cells are attacked by carcinogens, GADD45A will quickly activate the defense mechanism within the cells to help cells repair damage. If necessary, it will even start the apoptosis program, inducing apoptosis, reducing angiogenesis, and other methods to clean up abnormal cells and maintain the health of the body.

The figure above explains the complex mechanism by which GADD45A exerts its anti-tumor effect by regulating DNA repair, DNA demethylation, and cell apoptosis.

Regulator of metabolism

In the battlefield of metabolism, GADD45A becomes a strategist, finely regulating the metabolic activity of fat cells. Imagine that when you sweat in the gym, GADD45A is also working hard in the "gym" in your body, helping your body burn fat more efficiently, maintain a healthy weight, and help with weight management.

The guardian of nerves

In the neurological world, GADD45A is a gentle guardian. It works in the brain to protect neurons from damage and slow the progression of neurodegenerative diseases. For groups like Alzheimer's patients, the presence of GADD45A can slow the progression of the disease.

Cardiovascular and cerebrovascular diseases

GADD45A plays a multifaceted role in cardiovascular disease. It is a key regulator of cellular stress and injury repair and may also be involved in cardiac pathological processes. More research is needed to further clarify the specific mechanisms and potential therapeutic applications of GADD45A in cardiovascular disease.

The story of GADD45A, a "superhero", is played out in our bodies every day. Professor Xavier Palomer and his team have brought the "heroes" of the microscopic world from behind the scenes to the front stage.
Based on the above findings, GADD45A is likely to be a potential target for the future treatment of cancer, metabolic diseases, cardiovascular diseases and neurodegenerative diseases.
However, to translate these findings into clinical practice, further studies are needed to precisely regulate the function of GADD45A and explore its specific mechanisms of action in specific diseases.

References

[1]Palomer,

[2] New Drug Information Database. KES-0001
https://synapse.zhihuiya.com/drug/91b411adea2c40ebaeaa4f5203df2df9

Written by: Xiaoyu

Review: Shuxia

Layout: Chu Han