Why is there a blood pressure limit when taking aspirin? Because high blood pressure is dangerous

Aspirin is a familiar drug that can inhibit platelet aggregation and prevent myocardial infarction and cerebral infarction. But people always ask Huazi, after platelets are inhibited, is it easy to have cerebral hemorrhage?

Hua Zi said that the occurrence of cerebral hemorrhage has nothing to do with aspirin, but is related to high blood pressure. However, aspirin can aggravate the consequences of cerebral hemorrhage. If blood pressure is not well controlled, aspirin and other antiplatelet drugs should be used with caution.

1. Only take aspirin if you have a risk of thrombosis If arteries develop atherosclerosis, the arteries will become narrow, affecting the blood supply to the heart, brain, kidneys and other organs. At the same time, hardened plaques may rupture when the arteries contract and spasm. The rough surface of the ruptured plaques will activate platelets to aggregate and form thrombi, thus causing infarction events.

Aspirin can inhibit platelet aggregation, so taking aspirin can prevent thrombosis when the plaque ruptures. However, if the plaque does not rupture, taking aspirin is "in vain" and the only thing you will suffer is the adverse reactions caused by aspirin.

Therefore, only people who are confirmed to be at risk of thrombosis can take aspirin under the guidance of a doctor, and aspirin cannot be used for "daily health care."

2. The cause of cerebral hemorrhage is high blood pressure. If the blood pressure of a person with high blood pressure cannot be well controlled, the tension of the artery will increase over a long period of time. The weak parts of the arterial wall will gradually bulge out, forming tiny sac-like structures called aneurysms. Many tiny aneurysms will form on the cerebral arteries of patients with high blood pressure. When the blood pressure rises suddenly, the aneurysm will easily rupture, causing cerebral hemorrhage.

Another cause of cerebral hemorrhage is cerebral vascular amyloid degeneration, the pathogenesis of which is unknown and is related to genetics and aging. Amyloid substances are deposited on cerebral blood vessels, causing vascular structural degeneration. When blood pressure rises, it is easy to cause blood vessels to rupture and bleed.

Whether it is aneurysm or cerebral vascular amyloid degeneration, hypertension is the main cause of cerebral hemorrhage.

3. Controlling blood pressure is the only way to safely carry out antiplatelet therapy. After an artery ruptures, the platelets in the blood come into contact with the rough surface of the ruptured area and are activated to aggregate, forming a thrombus to help stop bleeding. However, after taking antiplatelet drugs such as aspirin, clopidogrel, and ticagrelor, the platelet aggregation function is inhibited. When a blood vessel ruptures, the hemostasis time will be prolonged, which will lead to worsening of cerebral hemorrhage.

Therefore, when taking antiplatelet therapy, it is required to control blood pressure. If blood pressure cannot be stably controlled below 160 mmHg, it is not recommended to take antiplatelet drugs such as aspirin to avoid increasing the risk of cerebral hemorrhage.

IV. Benefits and risks of drug treatment Huazi often compares drug treatment to "gambling" because no matter what drug is used, there will be both benefits of drug efficacy and risks of adverse reactions. Only when the benefits of drug treatment far outweigh the risks can treatment be carried out.

According to big data, for patients at high risk of thrombotic diseases, the use of antiplatelet drugs represented by aspirin can prevent the disease with a probability of more than 10%, while the risk of cerebral hemorrhage is only a few in ten thousand.

For people at risk of stroke, the probability of ischemic stroke (cerebral infarction) is 80%, and the probability of hemorrhagic stroke (cerebral hemorrhage) is 20%, so there is a high probability that they will benefit from taking aspirin.

5. How to reduce the probability of cerebral hemorrhage

1. Only use when necessary: ​​People with myocardial infarction, cerebral infarction, coronary heart disease, carotid artery stenosis of more than 50%, and those who have undergone stenting or bypass surgery need antiplatelet therapy. Antiplatelet therapy is not recommended for people who have not suffered from related diseases, unless the doctor assesses that the probability of cardiovascular and cerebrovascular diseases is very high.

2. Control blood pressure: People with high blood pressure should control their blood pressure below 160 mmHg while taking antiplatelet drugs such as aspirin.

3. Take small doses: Take small doses of aspirin (75mg~150mg per day). The usual dose is 100mg per day. Do not exceed the dose.

4. Adverse reaction monitoring: During medication, if symptoms such as subcutaneous bruising and gingival bleeding occur, the coagulation function should be checked. Those with normal function can continue to take the medication, while those with decreased function should reduce the dosage or stop taking the medication.

In summary, when using aspirin to prevent thrombotic diseases, you need to pay attention to controlling blood pressure not to exceed 160 mmHg to reduce the probability of cerebral hemorrhage. However, no matter how you reduce the probability, there will still be a certain risk, so you also need good luck during treatment.

Medicines need to be used under the guidance of a doctor. If you have any questions about medication, please consult a doctor or pharmacist. I am pharmacist Huazi. Welcome to follow me and share more health knowledge.