Can I take Metoclopramide while breastfeeding?

It is best not to take any medication during breastfeeding, because the medication will enter the baby's body through breast milk and cause certain harm. Metoclopramide is a drug that is beneficial to the gastrointestinal tract. So can I take Metoclopramide during breastfeeding? Metoclopramide cannot be taken casually. Even normal people have to take it according to the doctor's instructions. Therefore, breastfeeding women are not suitable for taking this medicine unless they stop breastfeeding during the medication period.

Metoclopramide is a peripheral dopamine receptor antagonist that can promote the peristalsis and tension of the upper gastrointestinal tract to return to normal, promote gastric emptying, increase intestinal motility of the gastric antrum and duodenum, coordinate the contraction of the pylorus, and also enhance the peristalsis of the esophagus and the tension of the lower esophageal sphincter. Because it has poor penetration into the blood-brain barrier and has almost no antagonistic effect on dopamine receptors in the brain, it can eliminate psychiatric and central nervous system side effects.

It is rapidly absorbed after oral administration, and the blood concentration reaches its peak in 15 to 30 minutes. Except for the central nervous system, it is widely distributed in other parts of the body. Due to the "first-pass effect" liver metabolism and intestinal wall metabolism, oral bioavailability is low. The half-life of this product is 7 hours. After oral administration, about 30% is excreted in the urine within 24 hours and about 60% is excreted in the feces within 4 days.

This product can block the effect of dopamine in the emetic chemosensory area and inhibit the occurrence of vomiting; it can promote the peristalsis and tension of the upper gastrointestinal tract to return to normal, and can accelerate gastric emptying after meals. In addition, it can also increase the tension of the cardiac sphincter and promote the expansion of the pyloric sphincter after meals. However, this product does not affect the secretion of gastric juice. Because it has a weak ability to pass through the blood-brain barrier, it has no obvious sedation, drowsiness, or extrapyramidal side effects.

To sum up, there are many contraindications for the use of Western medicine, such as it is contraindicated for patients with pheochromocytoma, breast cancer, mechanical intestinal obstruction, gastrointestinal bleeding and other diseases. Domperidone suspension is recommended for children. Use with caution in pregnant women. Patients with heart disease (arrhythmia) and cancer patients receiving chemotherapy should use it with caution as it may aggravate heart rhythm disorders. In case of overdose or serious adverse reactions, please seek medical attention immediately. It is prohibited to use the drug when its properties change.

Therefore, pregnant women should not take metoclopramide and must be cautious when using the medication.