What are the drugs that shrink the uterus after childbirth?

After giving birth, you definitely need to pay more attention to all aspects, especially physical conditioning, which must be done well. Otherwise, once you get sick, you will be left with lifelong pain and it will also affect the growth and development of your child. This is why women in our country have paid attention to confinement since ancient times. All female friends must keep this in mind. So, what are the drugs that promote uterine contraction after childbirth?

Amino acid ergotamines

Dihydrorgotoxine (Hydroxyergotoxine)

Hydroergotamine is a reduced dihydrogen derivative of ergot and has different effects from ergot.

By blocking α receptors, it can lead to peripheral vasodilation, lower blood pressure, slow heart rate, and reverse the adrenaline pressor effect. It is clinically used to treat vasospastic diseases.

Hydroergoline also has a central nervous system sedative effect. It can be combined with promethazine and pethidine to form a hibernation mixture, which is clinically used for artificial hibernation.

The main adverse reaction of this product is orthostatic hypotension, so the patient should stay in bed for 2 hours after injection. It is contraindicated for patients with hypotension, severe arteriosclerosis, coronary heart disease, renal insufficiency, etc.

Ergotamine

Ergotamine can constrict cerebral blood vessels, reduce the pulsation amplitude of cerebral arteries, and relieve migraines with an effectiveness rate of up to 90%, but it cannot prevent attacks. Since ergotamine is absorbed slowly and irregularly, it is often used in combination with caffeine, which can both increase the absorption of ergotamine and constrict cerebral blood vessels, thereby exerting a synergistic effect. Long-term use can damage vascular endothelial cells and cause branch necrosis, so oral administration is limited to 2-4 days.

Prostaglandins

Prostaglandins are a class of autologous active substances that are widely present in various tissues and fluids of the body and can now be synthesized artificially. Prostaglandins closely related to reproductive pharmacology include prostaglandin E2, prostaglandin F2α and its derivative 15-methylprostaglandin F2α.

(1) Dinoprostone (prostaglandin E2)

Function and use:

① Excite the uterus: It has obvious excitation and contraction effect on the uterus at all stages of pregnancy. Its effect on uterine contraction in early and mid-pregnancy is much stronger than that of oxytocin, and it is most sensitive to the uterus before delivery. The characteristics of causing uterine contractions are similar to those during childbirth. While enhancing the rhythmic contractions of uterine smooth muscles, it can also relax the muscles of the uterine neck.

It is used for induction of labor in mid-term pregnancy and full-term pregnancy. It is a safe and effective induction drug. In addition to intravenous infusion, administration into the vagina, into the amniotic cavity, or into the uterine cavity or outside the amniotic cavity can excite the uterus in early and mid-pregnancy and induce miscarriage. For inducing labor in early pregnancy, the required dose is large, which can easily cause more serious adverse reactions and is often difficult for pregnant women to tolerate.

② Anti-early pregnancy: Prostaglandin E2 can promote the atrophy and dissolution of the corpus luteum, causing a sharp drop in the level of progesterone in the blood, and the shedding of the endometrium to form menstruation. For women with early pregnancy within 49 days of amenorrhea, the effect of inducing menstruation and terminating pregnancy can reach 96%. In addition, it can promote uterine contraction, hinder the implantation of the fertilized egg and play an anti-early pregnancy role.