Is it normal for women to have positive blocking antibodies?

Many families who have been married for many years but have not been able to conceive successfully are always full of expectations for their baby. Many of them have been pregnant once but have had miscarriages due to physical reasons. They are always particularly careful. After conditioning, they want to prepare for pregnancy and always go to the hospital for a check-up. The blocking antibodies are positive. Let's find out whether it is normal for women to have positive blocking antibodies.

Is it normal for women to have positive blocking antibodies?

In the serum of normal pregnant women, there is a specific IgG antibody against spouse lymphocytes, which can inhibit lymphocyte response (MLR), block the cytotoxic effect of maternal lymphocytes on cultured trophoblasts, prevent helper T cells from recognizing inhibitors of fetal antigens, and prevent the mother's immune system from attacking the embryo. Blocking antibodies (BA) are antibodies that block the production of macrophage migration inhibitory factor (MIF) by lymphocytes stimulated by the same antigen.

95% of normal women who are not pregnant have negative blocking antibodies. Blocking antibodies are protective antibodies. After pregnancy, most people will be positive for blocking antibodies. Only patients with recurrent miscarriages need active immunotherapy. Waiting until the blocking antibodies turn positive before getting pregnant can reduce the chance of miscarriage by 80%. In this case, it is normal for pregnancy to be positive.

For those who lack blocking antibodies and anti-idiotypic antibodies, the main method used is spouse's leukocyte immunotherapy, which can increase the level of blocking antibodies in patients with recurrent spontaneous abortion. After the antibodies rise, pregnancy can be arranged to ensure successful pregnancy. During the treatment, medical staff drew a certain amount of peripheral blood from the husband for centrifugal sedimentation to separate and culture lymphocytes, and then infused them back into the skin of his wife's forearm. One cycle is done every 4 weeks, and this continues until the wife is four or five months pregnant to ensure that she has a normal pregnancy!

Treatment Process

1. In clinical practice, the first thing to do is to communicate and understand the patient more comprehensively, ensure that both husband and wife agree to undergo blocking antibody testing, and also have a certain understanding of the patient's medical history.

2. Before deciding to start treatment, men need to check whether they have any infectious diseases. If they are not infectious, they can undergo corresponding immune tests. Women need to avoid the menstrual period when undergoing the test.

3. After drawing the corresponding blood from men, they need to go through a sterile operation to separate the lymphocytes in the blood and make appropriate adjustments. The extracted lymphocytes can be used for immunotherapy in women.

4. After treatment, if the result shows that the blocking antibody is still negative, then women need to continue treatment. If it has turned positive, then they can consider trying to get pregnant, and they will need to continue treatment after pregnancy. During the treatment period, female friends should avoid sexual intercourse to avoid affecting the effect of treatment.

Is it normal for women to test positive for blocking antibodies? This is a question that many women are concerned about. This is a normal phenomenon. Women who can have normal pregnancy should be prepared for pregnancy when they test positive for blocking antibodies. They should start taking folic acid three months before pregnancy. Don't always be too nervous and treat pregnancy with a normal mind. In addition, you must maintain an optimistic attitude during pregnancy, pay more attention to rest and a balanced diet, avoid strenuous exercise, and do regular prenatal examinations.