How to improve the success rate of ovulation induction

Under normal circumstances, women will only ovulate one egg per month, and the number of ovulations a woman ovulates in her lifetime is limited. However, women with ovulation disorders will have their fertility affected. At this time, the doctor will choose ovulation induction treatment to achieve successful conception. So, what are the current treatments for ovulation induction? Below we introduce the treatments for ovulation induction in detail.

Ovulation-stimulating drugs

The commonly used ovulation-inducing drugs in clinical practice include clomiphene citrate (also known as clomiphene citrate or clomiphene citrate), gonadotropin, gonadotropin-releasing hormone (GnRH), bromocriptine, etc.

(l) Clomiphene: It is a synthetic non-steroidal compound with strong anti-estrogen effects. Its mechanism of promoting ovulation is mainly to compete with estrogen for receptors located in the hypothalamus, blocking the negative feedback effect of endogenous estrogen on the hypothalamus, thereby increasing the secretion of gonadotropin and inducing ovulation. The ovulation recovery rate of clomiphene can reach 70% to 80%, and the pregnancy rate is about 30% to 40%. The treatment range includes anovulatory menstruation, luteal insufficiency, amenorrhea and lactation syndrome, pituitary tumors, etc.

(2) Human gonadotropin (hMG): Each hMG contains 75 international units of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which is injected intramuscularly and is ineffective when taken orally. Its function is to directly stimulate the growth, development and maturation of follicles and secrete large amounts of estrogen. If it is ineffective when used alone, HCG can be used together to induce ovulation. The main indication for hMG/hCG ovulation induction is endogenous pituitary gonadotropin deficiency or insufficiency, such as Sheehan's disease. It is also suitable for insufficient hypothalamic GnRH secretion or ineffectiveness of clomiphene. The ovulation rate is about 90% and the pregnancy rate is 50% to 70%.

(3) Gonadotropin-releasing hormone (GnRH): GnRH is secreted by hypothalamic nerve cells. When it enters the anterior pituitary through the pituitary portal system, it stimulates pituitary gonadotropins to synthesize and release FSH and LH, thereby stimulating follicle development, maturation and ovulation. Pulse GnRH therapy is suitable for those who have no ovulation due to mental stress, malnutrition, long-term use of certain drugs (such as reserpine, phenothiazines, etc.) or contraceptives, which have an inhibitory effect on the hypothalamus, or when the cause cannot be found.

(4) Bromocriptine: It is a prolactin inhibitor that acts on the prolactin cells of the hypothalamus and pituitary, causing a decrease in blood prolactin, restoring the function of gonadal hormone secretion, promoting ovulation, and restoring menstruation. It is suitable for hyperprolactinemia.

The above are the drug treatments for ovulation induction. Once female friends find that they have difficulty conceiving, they should go to the hospital to confirm whether it is an ovulation disorder. It should be noted that ovulation induction drugs must be used under the guidance of a doctor and should not be used without authorization. If any adverse reaction occurs, consult a doctor immediately to avoid delaying the treatment.