What are the five coagulation tests?

Some people in life have difficulty stopping bleeding or occasional cyanosis of the skin. This situation is often related to their own blood coagulation function, mostly due to poor blood coagulation function. Doctors generally recommend five coagulation tests to ensure the condition of the body. In daily life, we should pay attention to supplementing vitamin K and eat more eggs and liver, which can restore normal blood coagulation. So what are the five coagulation tests?

The five coagulation tests mainly include plasma prothrombin time (PT), activated partial prothrombin time (APTT), fibrinogen (FIB), thrombin time (TT), D-dimer (DD), and international normalized ratio (INR).

PT: Mainly reflects the status of the extrinsic coagulation system, among which INR is often used to monitor oral anticoagulants. Prolongation is seen in congenital coagulation factor II, V, X and X deficiency and fibrinogen deficiency, while acquired coagulation factor deficiency is mainly seen in vitamin K deficiency, severe liver disease, hyperfibrinolysis, DIC, oral anticoagulants, etc.; shortening is seen in hypercoagulable state of blood and thrombotic diseases, etc.

APTT: Mainly reflects the status of the endogenous coagulation system and is often used to monitor heparin dosage. Increased levels are seen in cases where plasma factor VIII, factor IX and factor XI levels are decreased, such as in hemophilia A, hemophilia B and factor XI deficiency; decreased levels are seen in cases where hypercoagulable states occur, such as when procoagulant substances enter the blood and the activity of coagulation factors increases.

FIB: mainly reflects the content of fibrinogen. Increased levels are seen in acute myocardial infarction, while decreased levels are seen in the consumptive hypocoagulable-lytic phase of DIC, primary fibrinolysis, severe hepatitis, and cirrhosis.

TT: mainly reflects the time it takes for fibrinogen to convert into fibrin. Increased levels are seen in the hyperfibrinolysis phase of DIC, hypo(a)fibrinogenemia, dyshemoglobinemia, and increased fibrinogen degradation products (FDPs) in the blood; decreased levels have no clinical significance.

INR: The international normalized ratio (INR) is calculated from the prothrombin time (PT) and the international sensitivity index (ISI) of the assay reagent. The use of INR makes PT measured by different laboratories and different reagents comparable, which facilitates the unification of medication standards.

The main significance of patients undergoing the five coagulation tests is to check whether there are any problems with the blood, so that doctors can understand the patient's condition in time and use the correct medication for treatment. It is best for patients to fast on the day of the five coagulation tests, so that the results of the test will be more accurate. After the test, the patient should show the results to the doctor for review, which can detect blood problems and prevent many accidents.